| pubmed-article:16081804 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16081804 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16081804 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:16081804 | lifeskim:mentions | umls-concept:C0439682 | lld:lifeskim |
| pubmed-article:16081804 | lifeskim:mentions | umls-concept:C1516348 | lld:lifeskim |
| pubmed-article:16081804 | lifeskim:mentions | umls-concept:C1332421 | lld:lifeskim |
| pubmed-article:16081804 | lifeskim:mentions | umls-concept:C1415846 | lld:lifeskim |
| pubmed-article:16081804 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16081804 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16081804 | pubmed:dateCreated | 2005-8-5 | lld:pubmed |
| pubmed-article:16081804 | pubmed:abstractText | ICOS is a new member of the CD28 family of costimulatory molecules that is expressed on activated T cells. Its ligand B7RP-1 is constitutively expressed on B cells. Although the blockade of ICOS/B7RP-1 interaction inhibits T cell-dependent Ab production and germinal center formation, the mechanism remains unclear. We examined the contribution of ICOS/B7RP-1 to the generation of CXCR5+ follicular B helper T (T(FH)) cells in vivo, which preferentially migrate to the B cell zone where they provide cognate help to B cells. In the spleen, anti-B7RP-1 mAb-treated or ICOS-deficient mice showed substantially impaired development of CXCR5+ T(FH) cells and peanut agglutinin+ germinal center B cells in response to primary or secondary immunization with SRBC. Expression of CXCR5 on CD4+ T cells was associated with ICOS expression. Adoptive transfer experiments showed that the development of CXCR5+ T(FH) cells was enhanced by interaction with B cells, which was abrogated by anti-B7RP-1 mAb treatment. The development of CXCR5+ T(FH) cells in the lymph nodes was also inhibited by the anti-B7RP-1 mAb treatment. These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo. | lld:pubmed |
| pubmed-article:16081804 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16081804 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16081804 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16081804 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16081804 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:TakedaKazuyos... | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:YagitaHideoH | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:KojimaYukoY | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:OkumuraKoK | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:AkibaHisayaH | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:HaradaNorihir... | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:MaJuanJ | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:UsuiYoshihiko... | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:YamazakiTomoh... | lld:pubmed |
| pubmed-article:16081804 | pubmed:author | pubmed-author:TezukaKatsuna... | lld:pubmed |
| pubmed-article:16081804 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16081804 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16081804 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:16081804 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16081804 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16081804 | pubmed:pagination | 2340-8 | lld:pubmed |
| pubmed-article:16081804 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16081804 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16081804 | pubmed:articleTitle | The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. | lld:pubmed |
| pubmed-article:16081804 | pubmed:affiliation | Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan. hisaya@med.juntendo.ac.jp | lld:pubmed |
| pubmed-article:16081804 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16081804 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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