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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-8-5
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pubmed:abstractText |
ICOS is a new member of the CD28 family of costimulatory molecules that is expressed on activated T cells. Its ligand B7RP-1 is constitutively expressed on B cells. Although the blockade of ICOS/B7RP-1 interaction inhibits T cell-dependent Ab production and germinal center formation, the mechanism remains unclear. We examined the contribution of ICOS/B7RP-1 to the generation of CXCR5+ follicular B helper T (T(FH)) cells in vivo, which preferentially migrate to the B cell zone where they provide cognate help to B cells. In the spleen, anti-B7RP-1 mAb-treated or ICOS-deficient mice showed substantially impaired development of CXCR5+ T(FH) cells and peanut agglutinin+ germinal center B cells in response to primary or secondary immunization with SRBC. Expression of CXCR5 on CD4+ T cells was associated with ICOS expression. Adoptive transfer experiments showed that the development of CXCR5+ T(FH) cells was enhanced by interaction with B cells, which was abrogated by anti-B7RP-1 mAb treatment. The development of CXCR5+ T(FH) cells in the lymph nodes was also inhibited by the anti-B7RP-1 mAb treatment. These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Blr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/ICOS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Icos protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2340-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16081804-Animals,
pubmed-meshheading:16081804-Antibodies, Monoclonal,
pubmed-meshheading:16081804-Antigens, CD28,
pubmed-meshheading:16081804-Antigens, CD40,
pubmed-meshheading:16081804-Antigens, CD80,
pubmed-meshheading:16081804-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:16081804-Antigens, Surface,
pubmed-meshheading:16081804-B-Lymphocyte Subsets,
pubmed-meshheading:16081804-Cell Differentiation,
pubmed-meshheading:16081804-Chemokines, CXC,
pubmed-meshheading:16081804-Female,
pubmed-meshheading:16081804-Germinal Center,
pubmed-meshheading:16081804-Immunization, Secondary,
pubmed-meshheading:16081804-Inducible T-Cell Co-Stimulator Ligand,
pubmed-meshheading:16081804-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:16081804-Membrane Glycoproteins,
pubmed-meshheading:16081804-Membrane Proteins,
pubmed-meshheading:16081804-Mice,
pubmed-meshheading:16081804-Mice, Inbred A,
pubmed-meshheading:16081804-Mice, Inbred BALB C,
pubmed-meshheading:16081804-Mice, Inbred C3H,
pubmed-meshheading:16081804-Mice, Inbred C57BL,
pubmed-meshheading:16081804-Mice, Inbred CBA,
pubmed-meshheading:16081804-Mice, Inbred DBA,
pubmed-meshheading:16081804-Mice, Knockout,
pubmed-meshheading:16081804-Mice, SCID,
pubmed-meshheading:16081804-Receptors, CXCR5,
pubmed-meshheading:16081804-Receptors, Chemokine,
pubmed-meshheading:16081804-Receptors, Cytokine,
pubmed-meshheading:16081804-Receptors, OX40,
pubmed-meshheading:16081804-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16081804-Spleen,
pubmed-meshheading:16081804-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:16081804-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16081804-Tumor Necrosis Factors
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pubmed:year |
2005
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pubmed:articleTitle |
The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
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pubmed:affiliation |
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan. hisaya@med.juntendo.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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