Linked Life Data

16081186

Source:http://linkedlifedata.com/resource/pubmed/id/16081186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2005-10-17
pubmed:abstractText
In the present study we show that the transcription factor Groucho/TLE1 (TLE1) is expressed in virtually all major cortical subdivisions, hippocampus, amygdala, and thalamus, as well as in the cerebellum of the adult rat brain. In both neocortex and subcortical structures, TLE1 expression was mostly localized to neurons. In addition to the expected nuclear localization, TLE1 immunoreactivity was also detected in apical dendritic shafts of neocortical layer III and V pyramidal cells and in Purkinje cell dendrites. These results demonstrate that TLE1 expression occurs in the mature nervous system and suggest that this protein may perform new functions outside of the nucleus in selected cortical and cerebellar neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
106-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Dendritic localization of the transcriptional co-repressor Groucho/TLE1 in cortical and cerebellar neurons.
pubmed:affiliation
Center for Neuronal Survival, Montreal Neurological Institute, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't