16081026

Source:http://linkedlifedata.com/resource/pubmed/id/16081026

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004368, umls-concept:C0035820, umls-concept:C0039198, umls-concept:C0542341, umls-concept:C1527148
pubmed:issue	6
pubmed:dateCreated	2005-8-5
pubmed:abstractText	The crucial role of regulatory cells in self-tolerance and autoimmunity has been clearly established in numerous types of regulatory cells, the majority of which are CD4(+) T cells. Much focus has been placed on thymically derived CD4(+)CD25(+) regulatory T cells, given that the depletion of this subset in murine models results in the spontaneous development of autoimmune diseases. These naturally occurring regulatory T cells are found to be functionally mature in the thymus, and exert suppression in a contact-dependent manner. Another important category of immunosuppressive cells consists of conditionally induced regulatory T cells such as Tr1, Th3, and various other CD4(+) lymphocytes. Understanding the development and regulatory functions of immunoregulatory cells may elucidate the etiology for loss of self-tolerance. This review will summarize the characteristics, developmental pathways, and functions of regulatory T cells, as well as their role in human autoimmune diseases including multiple sclerosis, rheumatoid arthritis, Myasthenia Gravis, Kawasaki disease, autoimmune polyglandular syndrome type II, type 1 diabetes, autoimmune lymphoproliferative syndrome, and systemic lupus erythematosus.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101128967
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1568-9972
pubmed:author	pubmed-author:AnsariAftab AAA, pubmed-author:GershwinM EricME, pubmed-author:LanRuth YRY, pubmed-author:LianZhe-XiongZX
pubmed:issnType	Print
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	351-63
pubmed:dateRevised	2005-11-16
pubmed:meshHeading	pubmed-meshheading:16081026-Autoimmune Diseases, pubmed-meshheading:16081026-CD4-Positive T-Lymphocytes, pubmed-meshheading:16081026-Cell Differentiation, pubmed-meshheading:16081026-Humans
pubmed:year	2005
pubmed:articleTitle	Regulatory T cells: development, function and role in autoimmunity.
pubmed:affiliation	Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, TB 192, One Shields Avenue, Davis, CA 95616, USA.
pubmed:publicationType	Journal Article, Review