Source:http://linkedlifedata.com/resource/pubmed/id/16079206
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2005-8-4
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| pubmed:abstractText |
The free radical theory of aging proposes that the accumulation of oxidative damage is a key component of the aging process. The discovery of F2-isoprostanes (F2-isoPs) and their establishment as a sensitive and accurate biomarker of lipid peroxidation represents a major advance for measuring the oxidative stress status of an organism. We have shown that plasma free and total (free plus esterified) F2-isoPs increase with age (185% and 66%, respectively), and that these increases are reduced by life-extending caloric restriction (50% and 23%, respectively). In addition, we found that levels of esterified F2-isoPs increase 68% with age in liver, and 76% with age in kidney. Caloric restriction modulated the age-related increase, reducing the esterified F2-isoPs levels 27% in liver and 35% in kidney. These age-related increases in esterified F2-isoPs levels correlate well with DNA oxidation, as measured by 8-oxodeoxyguanosine production demonstrating that F2-isoPs are an excellent biomarker for age-related changes in oxidative damage to membranes.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-oxo-7-hydrodeoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/F2-Isoprostanes
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1079-5006
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
60
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
847-51
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16079206-Age Factors,
pubmed-meshheading:16079206-Aging,
pubmed-meshheading:16079206-Animal Nutritional Physiological Phenomena,
pubmed-meshheading:16079206-Animals,
pubmed-meshheading:16079206-Biological Markers,
pubmed-meshheading:16079206-Caloric Restriction,
pubmed-meshheading:16079206-Chromatography, High Pressure Liquid,
pubmed-meshheading:16079206-Chromatography, Thin Layer,
pubmed-meshheading:16079206-DNA,
pubmed-meshheading:16079206-Deoxyguanosine,
pubmed-meshheading:16079206-F2-Isoprostanes,
pubmed-meshheading:16079206-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:16079206-Kidney,
pubmed-meshheading:16079206-Lipid Peroxidation,
pubmed-meshheading:16079206-Liver,
pubmed-meshheading:16079206-Male,
pubmed-meshheading:16079206-Oxidative Stress,
pubmed-meshheading:16079206-Rats,
pubmed-meshheading:16079206-Rats, Inbred F344
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| pubmed:year |
2005
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| pubmed:articleTitle |
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels.
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| pubmed:affiliation |
Department of Physiology-MSC-7756, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA. wardw@uthscsa.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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