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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-9-19
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pubmed:abstractText |
The molecular mechanisms by which dendritic cells (DC) favor naive T cell survival in mice have been examined in co-cultures of DC and naive CD4+ T cells. Naive T cells can survive in the presence of IL-4 or IL-7, but DC-induced T cell survival requires direct cell-cell interactions and does not seem to be mediated by these or other soluble factors. Classical MHC II molecules on DC are not necessary for T cell survival as long as hybrid AalphaEbeta MHC class II molecules are present. In the total absence of MHC II molecules on DC, T cell survival is reduced by half, and CD3zeta phosphorylation fully disappears. These results contrast with the classical view that naive T cell survival is associated with CD3zeta phosphorylation and depends mostly on IL-7 and MHC-TCR interactions. We demonstrate that DC-induced T cell survival is a multi-factorial process that also involves CD28, LFA-1 and another (as yet undefined) surface molecule that requires the activity of src (but not phosphatidylinositol-3-) kinase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/CD3 antigen, zeta chain,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2563-72
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16078277-Animals,
pubmed-meshheading:16078277-Antigens, CD28,
pubmed-meshheading:16078277-Antigens, CD3,
pubmed-meshheading:16078277-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16078277-Cell Communication,
pubmed-meshheading:16078277-Cell Survival,
pubmed-meshheading:16078277-Coculture Techniques,
pubmed-meshheading:16078277-Dendritic Cells,
pubmed-meshheading:16078277-Flow Cytometry,
pubmed-meshheading:16078277-Histocompatibility Antigens Class II,
pubmed-meshheading:16078277-Immunoblotting,
pubmed-meshheading:16078277-Interleukin-4,
pubmed-meshheading:16078277-Interleukin-7,
pubmed-meshheading:16078277-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:16078277-Mice,
pubmed-meshheading:16078277-Mice, Inbred C57BL,
pubmed-meshheading:16078277-Mice, Knockout,
pubmed-meshheading:16078277-Phosphorylation,
pubmed-meshheading:16078277-src-Family Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells.
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pubmed:affiliation |
Département de Biologie Cellulaire, Institut Cochin, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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