Gastric carcinoma more commonly affects older patients, and it is thought that cases of early-onset gastric carcinoma may develop with a different molecular profile different from that of carcinoma occurring at a later age. We assayed the methylation status and genetic changes in genes associated with the APC-beta-catenin axis and the mismatch repair system in relatively early-onset gastric carcinoma samples to determine their association with gastric carcinogenesis.
Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Asan Medical Center 388-1, Pungnap-dong, Songpa-gu, Seoul, Korea. hckim@amc.seoul.kr
