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pubmed-article:16061837pubmed:abstractTextNon-linear relations between multiple biochemical parameters are the basis for the diagnosis of many diseases. Traditional linear analytical methods are not reliable predictors. Novel nonlinear techniques are increasingly used to improve the diagnostic accuracy of automated data interpretation. This has been exemplified in particular for the classification and diagnostic prediction of cancers based on expression profiling data. Our objective was to predict the genotype from complex biochemical data by comparing the performance of experienced clinicians to traditional linear analysis, and to novel non-linear analytical methods.lld:pubmed
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pubmed-article:16061837pubmed:articleTitleMachine learning approaches for phenotype-genotype mapping: predicting heterozygous mutations in the CYP21B gene from steroid profiles.lld:pubmed
pubmed-article:16061837pubmed:affiliationInternational NRW Graduate School in Bioinformatics and Genome Research Center of Biotechnology (CeBiTec), Bielefeld University, Germany. klaus.prank@cebitec.uni-bielefeld.delld:pubmed
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