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rdf:type |
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lifeskim:mentions |
umls-concept:C0008546,
umls-concept:C0017262,
umls-concept:C0036341,
umls-concept:C0162783,
umls-concept:C0311400,
umls-concept:C0332281,
umls-concept:C0681850,
umls-concept:C1515926,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-2
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pubmed:abstractText |
Schizophrenia is frequently accompanied by hypometabolism and altered gene expression in the prefrontal cortex. Cellular metabolism regulates chromatin structure, including covalent histone modifications, which are epigenetic regulators of gene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0003-990X
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pubmed:author |
pubmed-author:AkbarianSchahramS,
pubmed-author:BakerStephen PSP,
pubmed-author:BlivenErinE,
pubmed-author:BunneyWilliam EWEJr,
pubmed-author:ConleyRobert CRC,
pubmed-author:GuoYinY,
pubmed-author:JonesEdward GEG,
pubmed-author:LuizLori ALA,
pubmed-author:PeranelliAmy CAC,
pubmed-author:RobertsRosalinda CRC,
pubmed-author:RuehlMartin GMG,
pubmed-author:TammingaCarol ACA
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
829-40
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pubmed:dateRevised |
2009-10-28
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pubmed:meshHeading |
pubmed-meshheading:16061760-Chromatin,
pubmed-meshheading:16061760-Down-Regulation,
pubmed-meshheading:16061760-Epigenesis, Genetic,
pubmed-meshheading:16061760-Gene Expression,
pubmed-meshheading:16061760-Gene Expression Profiling,
pubmed-meshheading:16061760-Histones,
pubmed-meshheading:16061760-Humans,
pubmed-meshheading:16061760-Immunoblotting,
pubmed-meshheading:16061760-Immunohistochemistry,
pubmed-meshheading:16061760-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16061760-Prefrontal Cortex,
pubmed-meshheading:16061760-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16061760-Schizophrenia
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pubmed:year |
2005
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pubmed:articleTitle |
Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia.
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pubmed:affiliation |
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry and Bioinformatics Unit, Information Services, University of Massachusetts Medical School, Worcester, MA 01604, USA. Schahram.akbarian@umassmed.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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