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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1992-7-23
|
pubmed:abstractText |
A novel approach to the study of proteins is the construction of chimeras consisting of a target protein fused to an immunoglobulin constant domain. These recombinant globulins have been used in the identification of ligand-receptor pairs, determination of functional consequences of receptor engagement, the elucidation of structural domains necessary for ligand binding, and as potential therapeutic agents.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0952-7915
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
4
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
216-9
|
pubmed:dateRevised |
2005-11-16
|
pubmed:meshHeading |
pubmed-meshheading:1605911-Animals,
pubmed-meshheading:1605911-Antibodies, Monoclonal,
pubmed-meshheading:1605911-Chimera,
pubmed-meshheading:1605911-Humans,
pubmed-meshheading:1605911-Immunoglobulins,
pubmed-meshheading:1605911-Ligands,
pubmed-meshheading:1605911-Recombinant Fusion Proteins,
pubmed-meshheading:1605911-Research,
pubmed-meshheading:1605911-Structure-Activity Relationship
|
pubmed:year |
1992
|
pubmed:articleTitle |
Recombinant globulins: novel research tools and possible pharmaceuticals.
|
pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington.
|
pubmed:publicationType |
Journal Article,
Review
|