Source:http://linkedlifedata.com/resource/pubmed/id/16056126
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2005-8-1
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pubmed:abstractText |
Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive deficits. High-resolution magnetic resonance imaging, surface-based image analytic methods, and neuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermal morphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically significant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and significant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AA 10417,
http://linkedlifedata.com/resource/pubmed/grant/AA 10820,
http://linkedlifedata.com/resource/pubmed/grant/DA 015875,
http://linkedlifedata.com/resource/pubmed/grant/K01 MH01733,
http://linkedlifedata.com/resource/pubmed/grant/NS3753,
http://linkedlifedata.com/resource/pubmed/grant/P41 RR13642,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA 017831,
http://linkedlifedata.com/resource/pubmed/grant/U24 AA014808
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0959-4965
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1285-90
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16056126-Adolescent,
pubmed-meshheading:16056126-Adult,
pubmed-meshheading:16056126-Brain Mapping,
pubmed-meshheading:16056126-Case-Control Studies,
pubmed-meshheading:16056126-Cerebellum,
pubmed-meshheading:16056126-Child,
pubmed-meshheading:16056126-Cognition,
pubmed-meshheading:16056126-Ethanol,
pubmed-meshheading:16056126-Female,
pubmed-meshheading:16056126-Humans,
pubmed-meshheading:16056126-Magnetic Resonance Imaging,
pubmed-meshheading:16056126-Male,
pubmed-meshheading:16056126-Memory,
pubmed-meshheading:16056126-Neuropsychological Tests,
pubmed-meshheading:16056126-Pregnancy,
pubmed-meshheading:16056126-Prenatal Exposure Delayed Effects,
pubmed-meshheading:16056126-Statistics as Topic,
pubmed-meshheading:16056126-Verbal Learning
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pubmed:year |
2005
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pubmed:articleTitle |
Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure.
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pubmed:affiliation |
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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