While clinical trials with antileukotrienes have shown overall beneficial effects in asthma, the factors that determine leukotriene dependent asthma are still unclear. A study was undertaken to determine whether or not leukotriene responsiveness in the airways correlates with endogenous leukotriene biosynthesis.
Division of Respiratory Medicine, Department of Medicine at Karolinska University Hospital Solna, Cenyre for Allergy Research at Karolinska Instituet, Stockholm, Sweden.