|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-8-3
|
|
pubmed:abstractText |
Addition of biodegradable polymer shells surrounding polymeric, drug-loaded microparticles offers the opportunity to control drug release rates. A novel fabrication method was used to produce microparticles with precise control of particle diameter and the thickness of the polymer shell. The effect of shell thickness on release of a model drug, piroxicam, has been clearly shown for 2- to 15-microm thick shells of poly(D,L-lactide) (PDLL) surrounding a poly(D,L-lactide-co-glycolide) (PLG) core and compared to pure PLG microspheres loaded with piroxicam. Furthermore, the core-shell microparticles are compared to microspheres containing blended polymers in the same mass ratios to demonstrate the importance of the core-shell morphology. Combining PDLL(PLG) microcapsules of different shell thicknesses allows nearly constant release rates to be attained for a period of 6 weeks.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-3549
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
94
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2013-22
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:16052542-Chemistry, Pharmaceutical,
pubmed-meshheading:16052542-Delayed-Action Preparations,
pubmed-meshheading:16052542-Drug Carriers,
pubmed-meshheading:16052542-Lactic Acid,
pubmed-meshheading:16052542-Microscopy, Confocal,
pubmed-meshheading:16052542-Microscopy, Electron, Scanning,
pubmed-meshheading:16052542-Microspheres,
pubmed-meshheading:16052542-Particle Size,
pubmed-meshheading:16052542-Piroxicam,
pubmed-meshheading:16052542-Polyesters,
pubmed-meshheading:16052542-Polyglycolic Acid,
pubmed-meshheading:16052542-Polymers,
pubmed-meshheading:16052542-Solubility,
pubmed-meshheading:16052542-Time Factors
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Small-molecule release from poly(D,L-lactide)/poly(D,L-lactide-co-glycolide) composite microparticles.
|
|
pubmed:affiliation |
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|
