| pubmed-article:16051921 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0010823 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C1425473 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C1425474 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:16051921 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16051921 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16051921 | pubmed:dateCreated | 2005-10-17 | lld:pubmed |
| pubmed-article:16051921 | pubmed:abstractText | Human cytomegalovirus virus (CMV) is a major cause of morbidity and mortality in immunocompromised individuals. Recently, a novel group of cytokines [interleukin (IL)-28A/B and IL-29, also termed interferon (IFN)-lambdas] has been described. Here, we demonstrate that intestinal epithelial cell (IEC) lines as well as murine and human colonic tissue express the IFN-lambda receptor subunits IL-28R and IL-10R2. IL-28A and IL-29 binding to their receptor complex activates ERK-1/2 and stress-activated protein kinase/c-Jun NH2-terminal kinase MAPKs and Akt, resulting in increased IL-8 protein expression. IFN-lambdas also induce phosphorylation of signal transducer and activator of transcription 1 and significantly increase mRNA expression of suppressor of cytokine signaling 3 and the antiviral proteins myxovirus resistance A and 2',5'-oligoadenylate synthetase. These signals result in an up to 83% reduction of cells positive for human CMV immediate-early protein after human CMV infection. In mice, IL-28A mRNA expression is upregulated after infection with murine CMV in vivo. Both IL-28A and IL-29 significantly decrease cell proliferation but have no effect on Fas-induced apoptosis. In conclusion, IECs express functional receptors for IFN-lambdas, which mediate antiviral and antiproliferative signals in IECs, suggesting a potential for therapeutic use in certain viral infections and as (antiproliferative) anticancer therapy. | lld:pubmed |
| pubmed-article:16051921 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16051921 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051921 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16051921 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16051921 | pubmed:issn | 0193-1857 | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:AdlerBarbaraB | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:BrandStephanS | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:EichhorstSöre... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:GökeBurkhardB | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:DieboldJoachi... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:DiepolderHelm... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:OtteJan-Miche... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:AuernhammerCh... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:ZitzmannKathr... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:DambacherJuli... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:BeigelFlorian... | lld:pubmed |
| pubmed-article:16051921 | pubmed:author | pubmed-author:OlszakTorsten... | lld:pubmed |
| pubmed-article:16051921 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16051921 | pubmed:volume | 289 | lld:pubmed |
| pubmed-article:16051921 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16051921 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16051921 | pubmed:pagination | G960-8 | lld:pubmed |
| pubmed-article:16051921 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16051921 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16051921 | pubmed:articleTitle | IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. | lld:pubmed |
| pubmed-article:16051921 | pubmed:affiliation | Department of Medicine II, University-Hospital Munich-Grosshadern, University of Munich, D-81377 Munich, Germany. stephan.brand@med.uni-muenchen.de | lld:pubmed |
| pubmed-article:16051921 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16051921 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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