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rdf:type |
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lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0009368,
umls-concept:C0010823,
umls-concept:C0014597,
umls-concept:C0017262,
umls-concept:C0021853,
umls-concept:C0086597,
umls-concept:C0185117,
umls-concept:C0442805,
umls-concept:C0591833,
umls-concept:C1425473,
umls-concept:C1425474,
umls-concept:C1710082,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2005-10-17
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pubmed:abstractText |
Human cytomegalovirus virus (CMV) is a major cause of morbidity and mortality in immunocompromised individuals. Recently, a novel group of cytokines [interleukin (IL)-28A/B and IL-29, also termed interferon (IFN)-lambdas] has been described. Here, we demonstrate that intestinal epithelial cell (IEC) lines as well as murine and human colonic tissue express the IFN-lambda receptor subunits IL-28R and IL-10R2. IL-28A and IL-29 binding to their receptor complex activates ERK-1/2 and stress-activated protein kinase/c-Jun NH2-terminal kinase MAPKs and Akt, resulting in increased IL-8 protein expression. IFN-lambdas also induce phosphorylation of signal transducer and activator of transcription 1 and significantly increase mRNA expression of suppressor of cytokine signaling 3 and the antiviral proteins myxovirus resistance A and 2',5'-oligoadenylate synthetase. These signals result in an up to 83% reduction of cells positive for human CMV immediate-early protein after human CMV infection. In mice, IL-28A mRNA expression is upregulated after infection with murine CMV in vivo. Both IL-28A and IL-29 significantly decrease cell proliferation but have no effect on Fas-induced apoptosis. In conclusion, IECs express functional receptors for IFN-lambdas, which mediate antiviral and antiproliferative signals in IECs, suggesting a potential for therapeutic use in certain viral infections and as (antiproliferative) anticancer therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2',5'-Oligoadenylate Synthetase,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IL28A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL29 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/OAS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin 28alpha receptor,
http://linkedlifedata.com/resource/pubmed/chemical/myxovirus resistance proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0193-1857
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pubmed:author |
pubmed-author:AdlerBarbaraB,
pubmed-author:AuernhammerChristoph JCJ,
pubmed-author:BeigelFlorianF,
pubmed-author:BrandStephanS,
pubmed-author:DambacherJuliaJ,
pubmed-author:DieboldJoachimJ,
pubmed-author:DiepolderHelmutH,
pubmed-author:EichhorstSören TST,
pubmed-author:GökeBurkhardB,
pubmed-author:OlszakTorstenT,
pubmed-author:OtteJan-MichelJM,
pubmed-author:ZitzmannKathrinK
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pubmed:issnType |
Print
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pubmed:volume |
289
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
G960-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16051921-2',5'-Oligoadenylate Synthetase,
pubmed-meshheading:16051921-Animals,
pubmed-meshheading:16051921-Apoptosis,
pubmed-meshheading:16051921-Cell Line, Tumor,
pubmed-meshheading:16051921-Cell Proliferation,
pubmed-meshheading:16051921-Colon,
pubmed-meshheading:16051921-Cytokines,
pubmed-meshheading:16051921-Cytomegalovirus Infections,
pubmed-meshheading:16051921-Epithelial Cells,
pubmed-meshheading:16051921-GTP-Binding Proteins,
pubmed-meshheading:16051921-Gene Expression Regulation,
pubmed-meshheading:16051921-Humans,
pubmed-meshheading:16051921-Interleukin-8,
pubmed-meshheading:16051921-Interleukins,
pubmed-meshheading:16051921-Intestinal Mucosa,
pubmed-meshheading:16051921-Mice,
pubmed-meshheading:16051921-Mice, Inbred C57BL,
pubmed-meshheading:16051921-Mitogen-Activated Protein Kinases,
pubmed-meshheading:16051921-Receptors, Cytokine,
pubmed-meshheading:16051921-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression.
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pubmed:affiliation |
Department of Medicine II, University-Hospital Munich-Grosshadern, University of Munich, D-81377 Munich, Germany. stephan.brand@med.uni-muenchen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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