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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-7-29
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pubmed:abstractText |
T cells bearing alphabeta T cell receptors (TCRs) recognize antigens in the form of peptides bound to class I or class II major histocompatibility proteins (MHC). TCRs on mature T cells are usually very specific for both peptide and MHC class and allele. They are picked out from a precursor population in the thymus by MHC-driven positive and negative selection. Here we show that the pool of T cells initially positively selected in the thymus contains many T cells that are very crossreactive for peptide and MHC and that subsequent negative selection establishes the MHC-restriction and peptide specificity of peripheral T cells. Our results also suggest that germline-encoded TCR variable elements have an inherent predisposition to react with features shared by all MHC proteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16051149-Alleles,
pubmed-meshheading:16051149-Animals,
pubmed-meshheading:16051149-Germ-Line Mutation,
pubmed-meshheading:16051149-Histocompatibility Antigens Class I,
pubmed-meshheading:16051149-Histocompatibility Antigens Class II,
pubmed-meshheading:16051149-Hybridomas,
pubmed-meshheading:16051149-Mice,
pubmed-meshheading:16051149-Mice, Inbred C57BL,
pubmed-meshheading:16051149-Mice, Transgenic,
pubmed-meshheading:16051149-Models, Immunological,
pubmed-meshheading:16051149-Models, Molecular,
pubmed-meshheading:16051149-Peptides,
pubmed-meshheading:16051149-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:16051149-T-Cell Antigen Receptor Specificity,
pubmed-meshheading:16051149-T-Lymphocytes,
pubmed-meshheading:16051149-Thymus Gland
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pubmed:year |
2005
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pubmed:articleTitle |
How the T cell repertoire becomes peptide and MHC specific.
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pubmed:affiliation |
Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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