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pubmed:abstractText |
An efficient and concise total synthesis of (+)-lentiginosine (1) starting from an L-tartaric acid-derived nitrone using organometallic addition, indium-catalyzed reduction, and ring-closing metathesis reaction as the key steps is reported. Structural analogues of (+)-1 have been also synthesized, and their inhibitory activity toward 22 commercially available glycosidases has been evaluated.
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pubmed:affiliation |
Dipartimento di Chimica Organica Ugo Schiff, Università di Firenze, ICCOM, CNR, via della Lastruccia 13, I-50019 Sesto Fiorentino (FI), Italy. francesca.cardona@unifi.it
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