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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2005-7-29
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pubmed:abstractText |
(+)-SCH 351448 (Na+ salt A) was synthesized employing ring-closing olefin metathesis reaction of an open diene diester intermediate for construction of the 28-membered macrodiolide structure. The open diene diester was prepared from the monomeric hydroxy carboxylic acid and two different olefin fragments. The monomeric hydroxy acid was synthesized via Julia-Julia coupling reaction of intermediates derived from the same olefinic fragments. Oxane units in these fragments were prepared by radical cyclization reactions of beta-alkoxyacrylates. Analogous SCH 351448 salts incorporating other mono- and divalent cations may be prepared. Under acidic conditions, SCH 351448 (Na+ salt A) was the most stable complex, but SCH 351448 (Ca2+ salt) and (Na+ salt B) appear to be physiologically important species.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-3263
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pubmed:author |
pubmed-author:ChoEun JinEJ,
pubmed-author:ChoiSoo YoungSY,
pubmed-author:ChungYoung KeunYK,
pubmed-author:JiMi KyungMK,
pubmed-author:KangEun JooEJ,
pubmed-author:KimHie-JoonHJ,
pubmed-author:KimJong-SeoJS,
pubmed-author:LahMyoung SooMS,
pubmed-author:LeeEunE,
pubmed-author:LeeSueg-GeunSG,
pubmed-author:LeeYoung EunYE,
pubmed-author:ShinDong MokDM
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6321-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
Stereoselective synthesis of (+)-SCH 351448: a unique ligand system for sodium, calcium, and other cations.
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pubmed:affiliation |
Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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