|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0021403,
umls-concept:C0022277,
umls-concept:C0042210,
umls-concept:C0205210,
umls-concept:C0205217,
umls-concept:C0259967,
umls-concept:C0332120,
umls-concept:C1545588,
umls-concept:C1707455,
umls-concept:C1708733
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2005-7-29
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|
pubmed:abstractText |
We evaluated whether the increased immunogenicity provided by an MF59-adjuvant influenza vaccine translates into increased protection among the elderly. Residents of 25 long-term care facilities received either the adjuvant or a non-adjuvant vaccine. The odds ratios (OR) of influenza-like illness were calculated for non-adjuvant vs. adjuvant vaccine recipients, also stratifying for chronic cardiovascular, respiratory, and renal diseases. The risk was higher for the non-adjuvant vaccine recipients and highest for those with respiratory disease (OR 2.27, 95% CI 1.09-4.82) and cardiovascular disease (OR 1.88; 95% CI 1.31-2.72). In this study the MF59-adjuvant vaccine provided superior clinical protection among the elderly, especially those with chronic diseases.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0950-2688
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:volume |
133
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
687-93
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|
pubmed:dateRevised |
2010-5-17
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pubmed:meshHeading |
pubmed-meshheading:16050515-Adjuvants, Immunologic,
pubmed-meshheading:16050515-Age Distribution,
pubmed-meshheading:16050515-Aged,
pubmed-meshheading:16050515-Aged, 80 and over,
pubmed-meshheading:16050515-Cohort Studies,
pubmed-meshheading:16050515-Confidence Intervals,
pubmed-meshheading:16050515-Female,
pubmed-meshheading:16050515-Follow-Up Studies,
pubmed-meshheading:16050515-Homes for the Aged,
pubmed-meshheading:16050515-Humans,
pubmed-meshheading:16050515-Immunization Schedule,
pubmed-meshheading:16050515-Incidence,
pubmed-meshheading:16050515-Influenza, Human,
pubmed-meshheading:16050515-Influenza Vaccines,
pubmed-meshheading:16050515-Italy,
pubmed-meshheading:16050515-Long-Term Care,
pubmed-meshheading:16050515-Male,
pubmed-meshheading:16050515-Nursing Homes,
pubmed-meshheading:16050515-Odds Ratio,
pubmed-meshheading:16050515-Polysorbates,
pubmed-meshheading:16050515-Risk Factors,
pubmed-meshheading:16050515-Sensitivity and Specificity,
pubmed-meshheading:16050515-Sex Distribution,
pubmed-meshheading:16050515-Squalene
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
Evidence of increased clinical protection of an MF59-adjuvant influenza vaccine compared to a non-adjuvant vaccine among elderly residents of long-term care facilities in Italy.
|
|
pubmed:affiliation |
Azienda Servizi Sanitari no. 3, Gemona, Alto Friuli, Italy. dip@ass3.sanita.fvg.it
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|
pubmed:publicationType |
Journal Article,
Comparative Study
|
