Linked Life Data

16050271

Source:http://linkedlifedata.com/resource/pubmed/id/16050271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-7-29
pubmed:abstractText
Increasing evidence indicates that ion channels are involved in the pathophysiology of cancer. The human ether-á-go-go-related gene (hERG) can be considered one of the most critical ion-channel encoding genes involved in the establishment and maintenance of neoplastic growth. In this review, evidence is presented to demonstrate that hERG channels are frequently over- and/or mis-expressed in many tumour cell lines as well as in primary human cancers. Moreover, many tumour cells, especially leukaemia cells, express a truncated isoform (hERG1B) along with the full length hERG1 protein, to form heterotetrameric channels. Three main functions relevant to tumour cell biology can be ascribed to hERG channel activity: (i) the control of cell proliferation, especially in leukaemias; (ii) the regulation of tumour cell invasiveness, possible through a physical and functional interaction with adhesion receptors of the integrin family; and (iii) the control of tumour cell neoangiogensis, through the modulation of angiogenic factor secretion. hERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1528-2511
pubmed:author
pubmed:issnType
Print
pubmed:volume
266
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-32; discussion 232-4
pubmed:dateRevised
2008-10-28
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Expression and role of hERG channels in cancer cells.
pubmed:affiliation
Department of Experimental Pathology and Oncology, University of Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't