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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-7-28
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pubmed:abstractText |
We examined a G-to-A single nucleotide polymorphism of the ATM gene, to determine if it influences hereditary non-polyposis colorectal cancer (HNPCC) age of onset. HNPCC is caused by mutations in mismatch repair genes, especially hMLH1 and hMSH2. ATM germline mutations have been associated with breast and digestive cancers. In a smaller European study, the G-to-A polymorphism was associated with an increased risk of developing an HNPCC-related cancer within HNPCC families.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0957-5243
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
749-53
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:16049814-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16049814-Adult,
pubmed-meshheading:16049814-Age of Onset,
pubmed-meshheading:16049814-Aged,
pubmed-meshheading:16049814-Aged, 80 and over,
pubmed-meshheading:16049814-Carrier Proteins,
pubmed-meshheading:16049814-Cell Cycle Proteins,
pubmed-meshheading:16049814-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:16049814-DNA Mutational Analysis,
pubmed-meshheading:16049814-DNA-Binding Proteins,
pubmed-meshheading:16049814-Female,
pubmed-meshheading:16049814-Genetic Testing,
pubmed-meshheading:16049814-Genotype,
pubmed-meshheading:16049814-Germ-Line Mutation,
pubmed-meshheading:16049814-Humans,
pubmed-meshheading:16049814-Male,
pubmed-meshheading:16049814-Middle Aged,
pubmed-meshheading:16049814-MutS Homolog 2 Protein,
pubmed-meshheading:16049814-Nuclear Proteins,
pubmed-meshheading:16049814-Polymerase Chain Reaction,
pubmed-meshheading:16049814-Polymorphism, Single Nucleotide,
pubmed-meshheading:16049814-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:16049814-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16049814-Survival Rate,
pubmed-meshheading:16049814-Tumor Suppressor Proteins,
pubmed-meshheading:16049814-United States
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pubmed:year |
2005
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pubmed:articleTitle |
ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States).
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pubmed:affiliation |
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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