Linked Life Data

16047381

Source:http://linkedlifedata.com/resource/pubmed/id/16047381

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-8-29
pubmed:abstractText
The expression of insulin-like growth factor binding proteins (IGFBPs) during the morphogenesis of lingual papillae of mice was examined by in situ hybridization. Among seven mouse IGFBPs, IGFBP-1, -6, and -7 mRNAs were not expressed in the tongue tissue. At E12, though no papillae have formed yet, IGFBP-2, -4, and -5 were expressed in the entire tongue epithelium. At E14, fungiform papillae appeared in the anterior region and circumvallate papillae were distinguished in the posterior region. Strong expression of IGFBP-5 was observed in the apical region of both fungiform and circumvallate papillae. At this stage, the epithelial elevation of filiform papillae was not clear; but IGFBP-5 was expressed in the apex. At E15, foliate papillae were distinguished and IGFBP-5 was expressed in the dorsal epithelium of ridges. In filiform papillae, IGFBP-3 was expressed in the core of the connective tissue. At E17, the expression of IGFBP-5 disappeared from the apical region of fungiform, filiform, foliate, and circumvallate papillae, whereas that of IGFBP-2 remained. This finding suggests that IGFBP-5 and -2 function to cause evagination of the epithelium into a raised structure. In the epithelium of trenches of foliate and circumvallate papillae, strong expression of IGFBP-4 was observed at E15 and E17. As previously suggested from a study on postnatal mice (Suzuki et al. J Comp Neurol 2005;482:74-84), IGFBP-4 acts in the epithelial invagination to form the trenches, grooves, or furrows of lingual papillae during development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1552-4884
pubmed:author
pubmed:copyrightInfo
Copyright 2005 Wiley-Liss, Inc
pubmed:issnType
Print
pubmed:volume
286
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
841-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16047381-Animals, pubmed-meshheading:16047381-Connective Tissue, pubmed-meshheading:16047381-Epithelium, pubmed-meshheading:16047381-Female, pubmed-meshheading:16047381-Immunohistochemistry, pubmed-meshheading:16047381-Insulin-Like Growth Factor Binding Protein 2, pubmed-meshheading:16047381-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:16047381-Insulin-Like Growth Factor Binding Protein 4, pubmed-meshheading:16047381-Insulin-Like Growth Factor Binding Protein 5, pubmed-meshheading:16047381-Insulin-Like Growth Factor Binding Proteins, pubmed-meshheading:16047381-Mice, pubmed-meshheading:16047381-Mice, Inbred Strains, pubmed-meshheading:16047381-Morphogenesis, pubmed-meshheading:16047381-Pregnancy, pubmed-meshheading:16047381-RNA, Messenger, pubmed-meshheading:16047381-Tongue
pubmed:year
2005
pubmed:articleTitle
Role of IGFBPs in the morphogenesis of lingual papillae.
pubmed:affiliation
Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan. suzuki@hoku-iryo-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't