Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2005-10-20
pubmed:abstractText
Gene-expression profiling has identified 3 major subgroups of diffuse large B-cell lymphoma (DLBCL): germinal center B-cell-like (GCB), activated B-cell-like (ABC), and primary mediastinal DLBCL (PMBCL). Using comparative genomic hybridization (CGH), we investigated the genetic alterations of 224 cases of untreated DLBCL (87 GCB-DLBCL, 77 ABC-DLBCL, 19 PMBCL, and 41 unclassified DLBCL) previously characterized by gene-expression profiling. The DLBCL subgroups differed significantly in the frequency of particular chromosomal aberrations. ABC-DLBCL had frequent trisomy 3, gains of 3q and 18q21-q22, and losses of 6q21-q22, whereas GCB-DLBCL had frequent gains of 12q12, and PMBCL had gains of 9p21-pter and 2p14-p16. Parallel analysis of CGH alterations, locus-specific gene-expression profiles, and global gene-expression signatures revealed that DNA amplifications and gains had a substantial impact on the expression of genes in the involved chromosomal regions, and some genes were overexpressed in a DLBCL subgroup-specific fashion. Unexpectedly, specific chromosomal alterations were associated with significant changes in gene-expression signatures that reflect various aspects of lymphoma cell biology as well as the host response to the lymphoma. In addition, gains involving the chromosomal region 3p11-p12 provided prognostic information that was statistically independent of the previously defined gene-expression-based survival model, thereby improving its predictive power.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-10337996, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-10361135, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-10556197, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-10676951, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-10954754, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11158605, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11241792, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11567628, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11719443, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11748286, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11793437, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11850073, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11895757, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-11895793, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-12075054, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-12181265, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-12297621, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-12414653, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-12900505, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-12933571, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-12975453, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-14976040, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-15215171, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-15337798, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-15374954, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-15671525, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-2648153, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-8608249, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-8652842, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-9166827, http://linkedlifedata.com/resource/pubmed/commentcorrection/16046532-9639522
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-4971
pubmed:author
pubmed-author:ArmitageJames OJO, pubmed-author:BeaSilviaS, pubmed-author:BrazielRitaR, pubmed-author:BurekChristofC, pubmed-author:ChanWing CWC, pubmed-author:ConnorsJoseph MJM, pubmed-author:DelabieJanJ, pubmed-author:FisherRichard IRI, pubmed-author:GascoyneRandy DRD, pubmed-author:GreinerTimothy CTC, pubmed-author:GroganThomas MTM, pubmed-author:HolteHaraldH, pubmed-author:JaffeElaine SES, pubmed-author:JehnPhilippP, pubmed-author:KochM FMF, pubmed-author:KvaloySteinS, pubmed-author:Lopez-GuillermoArmandoA, pubmed-author:Lymphoma/Leukemia Molecular Profiling Project, pubmed-author:MontserratEmiliE, pubmed-author:MorenoVictorV, pubmed-author:Muller-HermelinkHans-KonradHK, pubmed-author:OttGermanG, pubmed-author:PowellJohnJ, pubmed-author:PuigXavierX, pubmed-author:RosenwaldAndreasA, pubmed-author:SalaverriaItziarI, pubmed-author:SimonRichardR, pubmed-author:SmelandErlend BEB, pubmed-author:StaudtLouis MLM, pubmed-author:WeisenburgerDennis DDD, pubmed-author:WilsonWyndham HWH, pubmed-author:WrightGeorgeG, pubmed-author:YangLimingL, pubmed-author:ZettlAndreasA
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3183-90
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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