| pubmed-article:16046526 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16046526 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16046526 | lifeskim:mentions | umls-concept:C0023473 | lld:lifeskim |
| pubmed-article:16046526 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16046526 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16046526 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16046526 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16046526 | pubmed:dateCreated | 2005-11-3 | lld:pubmed |
| pubmed-article:16046526 | pubmed:abstractText | To study natural killer (NK) cell-mediated antileukemic activity in chronic myelogenous leukemia (CML), we investigated the ability of HLA-matched and mismatched CD56(+) cells to inhibit granulocyte macrophage-colony-forming unit (CFU-GM) formation by leukemic CD34(+) cells. In 14 HLA-identical donor-recipient pairs, donor CD56(+) cells inhibited CML CFU-GM comparably to effectors from 14 HLA-mismatched unrelated individuals (mean inhibition 42% +/- 9% vs 39.5% +/- 7% at a 10:1 effector-to-target (E/T) ratio), suggesting that killer inhibitory receptor (KIR) incompatibility was not essential for an antileukemic effect. Both CD56(+)CD3(-) (natural killer [NK]) and CD56(+)CD3(+)(NK-T) cells inhibited CFU-GM growth of CML but not normal CD34(+) cells. A mechanism for this leukemia-specific cytotoxicity was suggested by the abnormal overexpression of major histocompatibility class I chain-related gene A or gene B (MICA/B) on CML CD34 cells and their ability to bind the NK activation ligand NKG2D. However, in vivo, CML cells may avoid NK-cell-mediated immune destruction by immune escape, shedding MICA into the plasma, thereby down-regulating NKG2D on CML CD56(+) cells. | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16046526 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16046526 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16046526 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16046526 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:FujiwaraHiros... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:BarrettA... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:FerroneSoldan... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:ProvenzanoMau... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:SconocchiaGiu... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:HenselNancyN | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:MelenhorstJos... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:RezvaniKatayo... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:LauMichelleM | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:WongsenaWacha... | lld:pubmed |
| pubmed-article:16046526 | pubmed:author | pubmed-author:LiJonmingJ | lld:pubmed |
| pubmed-article:16046526 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16046526 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16046526 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:16046526 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16046526 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16046526 | pubmed:pagination | 3666-72 | lld:pubmed |
| pubmed-article:16046526 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:meshHeading | pubmed-meshheading:16046526... | lld:pubmed |
| pubmed-article:16046526 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16046526 | pubmed:articleTitle | The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions. | lld:pubmed |
| pubmed-article:16046526 | pubmed:affiliation | Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung and Blood Institute, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:16046526 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16046526 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16046526 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16046526 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16046526 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16046526 | lld:pubmed |
