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rdf:type |
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lifeskim:mentions |
umls-concept:C0016059,
umls-concept:C0025914,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0026809,
umls-concept:C0034067,
umls-concept:C0064833,
umls-concept:C0208973,
umls-concept:C0332120,
umls-concept:C1517892,
umls-concept:C1704666,
umls-concept:C1705492
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pubmed:dateCreated |
2005-8-11
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pubmed:abstractText |
The separation of emphysema from fibrosis is not as clear-cut as it was thought in early studies. These two pathologies may be present at the same time in human lungs and in mice either instilled with elastolytic enzymes or bleomycin or exposed to cigarette-smoke. According to a current view, emphysema originates from a protease/antiprotease imbalance, and a role for antiproteases has also been suggested in the modulation of the fibrotic process. In this study we investigate in experimental animal models of emphysema and fibrosis whether neutrophil elastase may constitute a pathogenic link between these two pathologies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-11177318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-11405528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-11451907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-11549550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-11790668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-11943590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-12570672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-12634787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-1372163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-14503550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-14503562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-14503563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-14621076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-15191913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-15245434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-15640318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-1655765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-2000380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-2222515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-4899604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-5337140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-6023510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-6185026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-6603478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-7089570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-7524566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-7876240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-8166647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-8202900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-8542145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-8569173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-8765327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-8943423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-9230758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-9412578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16045796-9736031
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16045796-Animals,
pubmed-meshheading:16045796-Bleomycin,
pubmed-meshheading:16045796-Disease Models, Animal,
pubmed-meshheading:16045796-Emphysema,
pubmed-meshheading:16045796-Evidence-Based Medicine,
pubmed-meshheading:16045796-Leukocyte Elastase,
pubmed-meshheading:16045796-Mice,
pubmed-meshheading:16045796-Mice, Inbred BALB C,
pubmed-meshheading:16045796-Mice, Inbred C57BL,
pubmed-meshheading:16045796-Mice, Inbred DBA,
pubmed-meshheading:16045796-Pulmonary Fibrosis,
pubmed-meshheading:16045796-Smoke,
pubmed-meshheading:16045796-Tobacco
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pubmed:year |
2005
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pubmed:articleTitle |
Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models.
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pubmed:affiliation |
Department of Physiopathology and Experimental Medicine, University of Siena, 53100 Siena, Italy. lucattelli@unisi.it
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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