|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2005-7-27
|
|
pubmed:abstractText |
The aim of this study was to evaluate the efficacy and toxicity of 5-fluorouracil (5-FU) and l-leucovorin (I-LV) in 50 patients with advanced or recurrent colorectal cancer in our institute. The dose of 5-FU was 600 mg/m2 and the dose of l-LV was 250 mg/m2. Objective response were 36.8% of patients who had administration of full-dose and 14.8% of patients who had the administration of reduced dose or prolonged interval. No significant difference was observed in clinical benefit rates between patients administrated in full-dose and patients in reduced dose or prolonged interval. Median survival time (MST) of patients in reduced dose or prolonged interval is longer than patients in full-dose. These data suggest that 5-FU/l-LV can be given in the outpatient and yields improved prognosis and minimal adverse reactions even in patients in reduced dose or prolonged interval.
|
|
pubmed:language |
jpn
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0385-0684
|
|
pubmed:author |
pubmed-author:ChibaNatsukoN,
pubmed-author:IshiokaChikashiC,
pubmed-author:KakudoYuichiY,
pubmed-author:KatoSatoshiS,
pubmed-author:KatoShunsukeS,
pubmed-author:OhoriHisatsuguH,
pubmed-author:OtsukaKazunoriK,
pubmed-author:SakayoriMasatoM,
pubmed-author:ShibataHiroyukiH,
pubmed-author:TakahashiMasanobuM,
pubmed-author:TakahashiShinS,
pubmed-author:YamauraGengoG,
pubmed-author:YasudaKatsuhiroK,
pubmed-author:YoshiokaTakashiT
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
32
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
991-5
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16044961-Adult,
pubmed-meshheading:16044961-Aged,
pubmed-meshheading:16044961-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16044961-Colonic Neoplasms,
pubmed-meshheading:16044961-Diarrhea,
pubmed-meshheading:16044961-Drug Administration Schedule,
pubmed-meshheading:16044961-Female,
pubmed-meshheading:16044961-Fluorouracil,
pubmed-meshheading:16044961-Humans,
pubmed-meshheading:16044961-Leucovorin,
pubmed-meshheading:16044961-Leukopenia,
pubmed-meshheading:16044961-Liver Neoplasms,
pubmed-meshheading:16044961-Lung Neoplasms,
pubmed-meshheading:16044961-Lymphatic Metastasis,
pubmed-meshheading:16044961-Male,
pubmed-meshheading:16044961-Middle Aged,
pubmed-meshheading:16044961-Rectal Neoplasms,
pubmed-meshheading:16044961-Retrospective Studies,
pubmed-meshheading:16044961-Survival Rate
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
[Retrospective analysis on efficacy and toxicity of 5-fluorouracil (5-FU) and l-leucovorin (l-LV) in advanced or recurrent colorectal cancer].
|
|
pubmed:affiliation |
Dept. of Clinical Oncology, Institute of Development, Aging and Cancer and Tohoku University Hospital, Tohoku University.
|
|
pubmed:publicationType |
Journal Article,
English Abstract
|
