rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2005-10-3
|
pubmed:abstractText |
Animal models have implicated the alpha(1)-adrenergic subtypes in cognitive functions relevant to schizophrenia, but no consensus exists with regard to the status of noradrenergic receptor populations in psychiatric patients. We focused on one alpha(1)-adrenergic subtype, the alpha(1A)-adrenergic receptor, and proposed that genetic variants within the regulatory region of this gene (ADRA1A) alter the expression of this receptor, influencing susceptibility toward schizophrenia.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0006-3223
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
58
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
435-9
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:16043131-Confidence Intervals,
pubmed-meshheading:16043131-DNA Mutational Analysis,
pubmed-meshheading:16043131-Female,
pubmed-meshheading:16043131-Gene Frequency,
pubmed-meshheading:16043131-Genetic Predisposition to Disease,
pubmed-meshheading:16043131-Genotype,
pubmed-meshheading:16043131-Humans,
pubmed-meshheading:16043131-Male,
pubmed-meshheading:16043131-Odds Ratio,
pubmed-meshheading:16043131-Polymorphism, Genetic,
pubmed-meshheading:16043131-Promoter Regions, Genetic,
pubmed-meshheading:16043131-Psychotic Disorders,
pubmed-meshheading:16043131-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:16043131-Schizophrenia,
pubmed-meshheading:16043131-Spain
|
pubmed:year |
2005
|
pubmed:articleTitle |
Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population.
|
pubmed:affiliation |
Department of Psychological Medicine, Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College, London, UK. Dan.clark@iop.kcl.ac.uk
|
pubmed:publicationType |
Journal Article,
Comparative Study
|