Linked Life Data

16041796

Source:http://linkedlifedata.com/resource/pubmed/id/16041796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-8-31
pubmed:abstractText
Chondroitin sulfate (ChS) was used to form polyelectrolyte complexes with chitosan (ChI), and its potential as a colon-targeted drug carrier was investigated. In order to determine the optimal conditions for the formation of a stable polyelectrolyte complex, the formation of ChS/ChI complexes was examined at two different pH values with various weight ratios, or at a fixed molar ratio of ChS/ChI of 1/2 under various pH conditions. The molar compositions of the various ChS/ChI complexes were quantitated with the use of solid-state 13C CP MAS NMR. The equivalent molar ratios of the complexes ranged from 0.47 to 0.54, in agreement with the data determined by elemental analysis. The fact that these values were close to 0.5 suggests that most of the --OSO3- and the --COO- groups on ChS formed strong electrostatic interactions with the --NH3+ groups on ChI, obeying a simple stoichiometric reaction between two oppositely charged moieties. Similar compositions of the complexes were obtained under most conditions tested; however, different strengths of the interactions between the two polysaccharides were noted from measurements of the water-associated transition and thermal degradation temperatures and the degree of ChS dissolution. FTIR and 13C NMR clearly showed H-bond formation at low pH, indicating that in addition to the varying degrees of electrostatic interaction, H bonding may be involved in complex formation. The highest degradation temperature, as determined by thermal gravimetric analysis, and the lowest ChS sol fraction, as measured by gel permeation chromatography, were observed with the complex prepared at pH 5, with a 1:1 mole ratio of the two opposite charges in feed. This complex also exhibited the highest water-associated transition temperature, as determined by differential scanning calorimetry. Furthermore, the swelling behavior of these complexes was pH dependent; this is a property that can potentially be exploited to control drug release from these complexes under specific pH conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1549-3296
pubmed:author
pubmed:copyrightInfo
(c) 2005 Wiley Periodicals, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
128-37
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16041796-Amines, pubmed-meshheading:16041796-Calorimetry, Differential Scanning, pubmed-meshheading:16041796-Carboxylic Acids, pubmed-meshheading:16041796-Chitin, pubmed-meshheading:16041796-Chitosan, pubmed-meshheading:16041796-Chondroitin Sulfates, pubmed-meshheading:16041796-Chromatography, pubmed-meshheading:16041796-Drug Delivery Systems, pubmed-meshheading:16041796-Electrolytes, pubmed-meshheading:16041796-Hot Temperature, pubmed-meshheading:16041796-Hydrogen Bonding, pubmed-meshheading:16041796-Hydrogen-Ion Concentration, pubmed-meshheading:16041796-Macromolecular Substances, pubmed-meshheading:16041796-Magnetic Resonance Spectroscopy, pubmed-meshheading:16041796-Models, Chemical, pubmed-meshheading:16041796-Molecular Weight, pubmed-meshheading:16041796-Polymers, pubmed-meshheading:16041796-Polysaccharides, pubmed-meshheading:16041796-Solubility, pubmed-meshheading:16041796-Spectroscopy, Fourier Transform Infrared, pubmed-meshheading:16041796-Temperature
pubmed:year
2005
pubmed:articleTitle
Characterization of polyelectrolyte complexes between chondroitin sulfate and chitosan in the solid state.
pubmed:affiliation
College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't