|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-8-23
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Fc receptor (FcR)-mediated phagocytosis requires activation of the Rho GTPases Cdc42 and Rac1, but how they are recruited to the FcR is unknown. Here we show that the calcium-promoted Ras inactivator (CAPRI), a Ras GTPase-activating protein, functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. CAPRI-deficient macrophages had impaired FcgammaR-mediated phagocytosis and oxidative burst, as well as defective activation of Cdc42 and Rac1. CAPRI interacted constitutively with both Cdc42 and Rac1 and translocated to phagocytic cups during FcgammaR-mediated phagocytosis. CAPRI-deficient mice had an impaired innate immune response to bacterial infection. These results suggest that CAPRI provides a link between FcgammaR and Cdc42 and Rac1 and is essential for innate immune responses.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-10209117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-10358769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-10586078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-10684859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-10934035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11101877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11244038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11448776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11708889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11790544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11861619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11950933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-11967541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-12488490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-12791976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-14691481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-16116463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-7500386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-7637787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-7935405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-8259209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-8530488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-8577722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-8601314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-8663235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-9143687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-9314552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-9348306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-9632805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-9751798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-9799231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041389-9831565
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1529-2908
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
6
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
911-9
|
|
pubmed:dateRevised |
2011-1-7
|
|
pubmed:meshHeading |
pubmed-meshheading:16041389-Animals,
pubmed-meshheading:16041389-Bacterial Infections,
pubmed-meshheading:16041389-Bone Marrow,
pubmed-meshheading:16041389-Cells, Cultured,
pubmed-meshheading:16041389-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:16041389-Macrophages, Peritoneal,
pubmed-meshheading:16041389-Membrane Glycoproteins,
pubmed-meshheading:16041389-Mice,
pubmed-meshheading:16041389-Mice, Inbred C57BL,
pubmed-meshheading:16041389-Mice, Knockout,
pubmed-meshheading:16041389-Molecular Sequence Data,
pubmed-meshheading:16041389-Phagocytosis,
pubmed-meshheading:16041389-Phosphorylation,
pubmed-meshheading:16041389-Receptors, Cell Surface,
pubmed-meshheading:16041389-Receptors, IgG,
pubmed-meshheading:16041389-Toll-Like Receptors,
pubmed-meshheading:16041389-cdc42 GTP-Binding Protein,
pubmed-meshheading:16041389-rac1 GTP-Binding Protein,
pubmed-meshheading:16041389-ras GTPase-Activating Proteins
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.
|
|
pubmed:affiliation |
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
