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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-7-25
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pubmed:abstractText |
This study reports the efficacy of a heterologous prime-boost vaccination using DNA and vaccinia viruses (Western Reserve [WR] virus and modified [attenuated] vaccinia virus Ankara [MVA]) expressing the LACK antigen (Leishmania homologue of receptors for activated C kinase) and an intradermal murine infection model employing Leishmania infantum. At 1 month postinfection, vaccinated mice showed high levels of protection in the draining lymph node (240-fold reduction in parasite burden) coupled with significant levels of gamma interferon (20 to 200 ng/ml) and tumor necrosis factor alpha/lymphotoxin (8 to 134 pg/ml). Significant but lower levels of protection (6- to 30-fold) were observed in the spleen and liver. Comparable levels of protection were found for mice boosted with either LACK-WR or LACK-MVA, supporting the use of an attenuated vaccinia virus-based vaccine against human visceral leishmaniasis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041057-10458764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041057-10507299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041057-10652464,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16041057-9990343
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5286-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16041057-Animals,
pubmed-meshheading:16041057-Antigens, Protozoan,
pubmed-meshheading:16041057-Immunization, Secondary,
pubmed-meshheading:16041057-Interferon-gamma,
pubmed-meshheading:16041057-Leishmania infantum,
pubmed-meshheading:16041057-Leishmaniasis, Visceral,
pubmed-meshheading:16041057-Mice,
pubmed-meshheading:16041057-Mice, Inbred BALB C,
pubmed-meshheading:16041057-Protozoan Proteins,
pubmed-meshheading:16041057-Protozoan Vaccines,
pubmed-meshheading:16041057-Spleen,
pubmed-meshheading:16041057-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16041057-Vaccinia virus
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pubmed:year |
2005
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pubmed:articleTitle |
Heterologous prime-boost vaccination with the LACK antigen protects against murine visceral leishmaniasis.
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pubmed:affiliation |
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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