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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-7-25
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pubmed:abstractText |
Resistant C57BL/6 mice infected in the lungs with Mycobacterium tuberculosis and then therapeutically vaccinated with Mycobacterium leprae-derived hsp65 DNA develop severe granulomatous pneumonia and tissue damage. Analysis of cells accumulating in the lungs of these animals revealed substantial increases in T cells secreting tumor necrosis factor alpha and CD8 cells staining positive for granzyme B. Stimulation of lung cells ex vivo revealed very high levels of interleukin-10, some of which was produced by B-1 B cells. This was probably an anti-inflammatory response, since lung pathology was dramatically worsened in B-cell gene-disrupted mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-10076914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-10092807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-10421369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-11083819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-11159955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-11179349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-11292688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-12654841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-14634116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-15187142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-15294094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-8705858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041037-8705859
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5189-93
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16041037-Animals,
pubmed-meshheading:16041037-Bacterial Proteins,
pubmed-meshheading:16041037-Chaperonin 60,
pubmed-meshheading:16041037-Chaperonins,
pubmed-meshheading:16041037-DNA,
pubmed-meshheading:16041037-Female,
pubmed-meshheading:16041037-Immunohistochemistry,
pubmed-meshheading:16041037-Lung,
pubmed-meshheading:16041037-Mice,
pubmed-meshheading:16041037-Mice, Inbred BALB C,
pubmed-meshheading:16041037-Mice, Inbred C57BL,
pubmed-meshheading:16041037-Mycobacterium leprae,
pubmed-meshheading:16041037-Mycobacterium tuberculosis,
pubmed-meshheading:16041037-Tuberculosis, Pulmonary
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pubmed:year |
2005
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pubmed:articleTitle |
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.
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pubmed:affiliation |
Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, 1682 Campus Delivery, Fort Collins, CO 80523-1682, USA. jltaylor@lamar.colostate.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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