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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-8-15
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pubmed:abstractText |
We provide genetic evidence to show that the Mycobacterium tuberculosis FtsZ and FtsW proteins interact, and that these interactions are biologically relevant. Furthermore, we show by fluorescence microscopy that Mycobacterium smegmatis FtsW is part of its septasomal complex and colocalizes with FtsZ to the midcell sites. Colocalization experiments reveal that approximately 27% of the cells with septal Z-rings contain FtsW whereas 93% of the cells with FtsW bands are associated with FtsZ indicating that FtsW is late recruit to the septum, as in Escherichia coli. Our results suggest that mycobacterial FtsZ can localize to the septum independent of FtsW, and that interactions of FtsW with FtsZ are critical for the formation of productive FtsZ-rings and the cell division process in mycobacteria.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0378-1097
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
250
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-17
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16040206-Aspartic Acid,
pubmed-meshheading:16040206-Bacterial Proteins,
pubmed-meshheading:16040206-Base Sequence,
pubmed-meshheading:16040206-Biological Transport, Active,
pubmed-meshheading:16040206-Cell Division,
pubmed-meshheading:16040206-Cytoskeletal Proteins,
pubmed-meshheading:16040206-Escherichia coli,
pubmed-meshheading:16040206-Genes, Bacterial,
pubmed-meshheading:16040206-Membrane Proteins,
pubmed-meshheading:16040206-Mycobacterium smegmatis,
pubmed-meshheading:16040206-Plasmids,
pubmed-meshheading:16040206-Recombinant Fusion Proteins,
pubmed-meshheading:16040206-Two-Hybrid System Techniques
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pubmed:year |
2005
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pubmed:articleTitle |
Genetic evidence that mycobacterial FtsZ and FtsW proteins interact, and colocalize to the division site in Mycobacterium smegmatis.
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pubmed:affiliation |
The University of Texas Health Center at Tyler, Biomedical Research, 11937 US Hwy 271, Tyler, TX 75708, United States. malini.rajagopalan@uthct.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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