Source:http://linkedlifedata.com/resource/pubmed/id/16040009
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2005-8-16
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| pubmed:abstractText |
The distribution of motor and proprioceptive neurons was investigated in the trigeminal nervous system of wild-type and Brn-3a knockout mice at embryonic day 18.5 and postnatal day 0. We found that the trigeminal motor nucleus (Mo5) contained abundant motoneurons in wild-type (mean number +/- SD per section = 128 +/- 22, range = 93-167) and knockout (mean number +/- SD per section = 121 +/- 23, range = 75-158) mice and that the cell size of Mo5 neurons was similar between these mice (wild-type, mean +/- SD = 165 +/- 59 microm2, range = 65-326 microm2; knockout, mean +/- SD = 167 +/- 59 microm2, range = 71-327 microm2). Mo5 neurons were immunoreactive for calcitonin gene-related peptide and such immunoreactive neurons were abundant in both wild-type and mutant mice. In the mesencephalic tract nucleus (Mes5) of wild-type mice, many proprioceptors (mean number +/- SD per section = 56 +/- 19, range = 27-85) that contained parvalbumin immunoreactivity were also observed. In knockout mice, however, Mes5 neurons could not be detected. The area of brainstems which normally contained the Mes5 was devoid of parvalbumin-immunoreactive proprioceptors. The present study suggests that Brn-3a is required for the development of proprioceptors but not motoneurons in the trigeminal nervous system.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Parvalbumins,
http://linkedlifedata.com/resource/pubmed/chemical/Pou4f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor Brn-3,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor Brn-3A,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
0006-8993
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
16
|
| pubmed:volume |
1053
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
203-6
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16040009-Animals,
pubmed-meshheading:16040009-Calcitonin Gene-Related Peptide,
pubmed-meshheading:16040009-Cell Count,
pubmed-meshheading:16040009-Cell Size,
pubmed-meshheading:16040009-DNA-Binding Proteins,
pubmed-meshheading:16040009-Embryo, Mammalian,
pubmed-meshheading:16040009-Gene Expression Regulation, Developmental,
pubmed-meshheading:16040009-Immunohistochemistry,
pubmed-meshheading:16040009-Mesencephalon,
pubmed-meshheading:16040009-Mice,
pubmed-meshheading:16040009-Mice, Knockout,
pubmed-meshheading:16040009-Motor Neurons,
pubmed-meshheading:16040009-Neurons, Afferent,
pubmed-meshheading:16040009-Parvalbumins,
pubmed-meshheading:16040009-Transcription Factor Brn-3,
pubmed-meshheading:16040009-Transcription Factor Brn-3A,
pubmed-meshheading:16040009-Transcription Factors,
pubmed-meshheading:16040009-Trigeminal Nuclei
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| pubmed:year |
2005
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| pubmed:articleTitle |
Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus.
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| pubmed:affiliation |
Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. hiroichi@md.okayama-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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