| pubmed-article:16039862 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16039862 | lifeskim:mentions | umls-concept:C0019369 | lld:lifeskim |
| pubmed-article:16039862 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16039862 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16039862 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:16039862 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16039862 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16039862 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:16039862 | pubmed:dateCreated | 2005-8-15 | lld:pubmed |
| pubmed-article:16039862 | pubmed:abstractText | Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2. | lld:pubmed |
| pubmed-article:16039862 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16039862 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16039862 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16039862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16039862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16039862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16039862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16039862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16039862 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16039862 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16039862 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:GudmundssonKr... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:AllenScott... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:SellesethDean... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:TurnerElizabe... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:JohnsBrian... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:WangZhichengZ | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:FreemanGeorge... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:CreechKatrina... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:BoydF... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:SextonConnie... | lld:pubmed |
| pubmed-article:16039862 | pubmed:author | pubmed-author:MoniriKelly... | lld:pubmed |
| pubmed-article:16039862 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16039862 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16039862 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16039862 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16039862 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16039862 | pubmed:pagination | 5346-61 | lld:pubmed |
| pubmed-article:16039862 | pubmed:meshHeading | pubmed-meshheading:16039862... | lld:pubmed |
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| pubmed-article:16039862 | pubmed:meshHeading | pubmed-meshheading:16039862... | lld:pubmed |
| pubmed-article:16039862 | pubmed:meshHeading | pubmed-meshheading:16039862... | lld:pubmed |
| pubmed-article:16039862 | pubmed:meshHeading | pubmed-meshheading:16039862... | lld:pubmed |
| pubmed-article:16039862 | pubmed:meshHeading | pubmed-meshheading:16039862... | lld:pubmed |
| pubmed-article:16039862 | pubmed:meshHeading | pubmed-meshheading:16039862... | lld:pubmed |
| pubmed-article:16039862 | pubmed:meshHeading | pubmed-meshheading:16039862... | lld:pubmed |
| pubmed-article:16039862 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16039862 | pubmed:articleTitle | Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses. | lld:pubmed |
| pubmed-article:16039862 | pubmed:affiliation | Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. Kristjan.gudmundsson@gsk.com | lld:pubmed |
| pubmed-article:16039862 | pubmed:publicationType | Journal Article | lld:pubmed |
