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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2005-8-15
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pubmed:abstractText |
Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:AllenScott HSH,
pubmed-author:BoydF LeslieFLJr,
pubmed-author:CreechKatrina LKL,
pubmed-author:FreemanGeorge AGA,
pubmed-author:GudmundssonKristjan SKS,
pubmed-author:JohnsBrian ABA,
pubmed-author:MoniriKelly RKR,
pubmed-author:SellesethDean WDW,
pubmed-author:SextonConnie JCJ,
pubmed-author:TurnerElizabeth MEM,
pubmed-author:WangZhichengZ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5346-61
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pubmed:meshHeading |
pubmed-meshheading:16039862-Animals,
pubmed-meshheading:16039862-Antiviral Agents,
pubmed-meshheading:16039862-Cell Line,
pubmed-meshheading:16039862-Cercopithecus aethiops,
pubmed-meshheading:16039862-Herpesvirus 1, Human,
pubmed-meshheading:16039862-Herpesvirus 2, Human,
pubmed-meshheading:16039862-Humans,
pubmed-meshheading:16039862-Microbial Sensitivity Tests,
pubmed-meshheading:16039862-Phenol,
pubmed-meshheading:16039862-Pyrazoles,
pubmed-meshheading:16039862-Pyridines,
pubmed-meshheading:16039862-Structure-Activity Relationship,
pubmed-meshheading:16039862-Vero Cells,
pubmed-meshheading:16039862-Virus Replication
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.
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pubmed:affiliation |
Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. Kristjan.gudmundsson@gsk.com
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pubmed:publicationType |
Journal Article
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