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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-12
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pubmed:abstractText |
This study examined reflex mechanisms that mediate urinary bladder and external urethral sphincter (EUS) coordination in female Sprague-Dawley urethane-anesthetized rats under empty and distended bladder conditions. The bladder was distended either by a small balloon or a saline filled catheter inserted through the body of the bladder. Stimulation of the entire pudendal nerve elicited short latency (8-12 ms) responses in the EUS and short (3-8 ms) and long latency responses (16-20 ms) in contralateral pudendal nerve. The long latency pudendal-pudendal reflex was reduced by 36.7% in area during bladder distension with the balloon catheter. However, there was no significant change in the area of pudendal-EUS reflex during bladder distension. Peak amplitudes of both reflexes were reduced 32% by bladder distension. The effects of glutamatergic receptor antagonists on the reflexes were also examined. MK 801 (0.3-5mg/kg, i.v.), an N-methyl-d-aspartate glutamatergic receptor antagonist, markedly depressed the pudendal-pudendal reflex, but LY 215490 (3mg/kg, i.v.), an alpha-amino-5-methyl isoxazole-4-propionate antagonist, had a minimal inhibitory effect. Both glutamatergic receptor antagonists significantly suppressed the pudendal-EUS reflex. These results indicate that the EUS is innervated by multiple pathways and that glutamatergic excitatory transmission is important in the neural mechanisms underlying bladder-sphincter coordination in the rat.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-10338308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-10737535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-11170195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-11312567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-11994813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-12117310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-15113743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-15540791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-15601736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-2477417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-2539452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-2758331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-2794345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-3332279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-3722467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-512936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-6277430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-7069620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-7069626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-7131318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-7698183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-8351765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-8496829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-9023304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-9296560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16039722-9593508
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0165-0270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
80-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16039722-Anesthetics, Intravenous,
pubmed-meshheading:16039722-Animals,
pubmed-meshheading:16039722-Axons,
pubmed-meshheading:16039722-Balloon Dilation,
pubmed-meshheading:16039722-Dizocilpine Maleate,
pubmed-meshheading:16039722-Electric Stimulation,
pubmed-meshheading:16039722-Excitatory Amino Acid Antagonists,
pubmed-meshheading:16039722-Female,
pubmed-meshheading:16039722-Isoquinolines,
pubmed-meshheading:16039722-Neurons, Afferent,
pubmed-meshheading:16039722-Rats,
pubmed-meshheading:16039722-Rats, Sprague-Dawley,
pubmed-meshheading:16039722-Receptors, Glutamate,
pubmed-meshheading:16039722-Reflex,
pubmed-meshheading:16039722-Tetrazoles,
pubmed-meshheading:16039722-Urethane,
pubmed-meshheading:16039722-Urethra,
pubmed-meshheading:16039722-Urinary Bladder
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pubmed:year |
2006
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pubmed:articleTitle |
Reflexes evoked by electrical stimulation of afferent axons in the pudendal nerve under empty and distended bladder conditions in urethane-anesthetized rats.
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pubmed:affiliation |
Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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