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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-9-28
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pubmed:abstractText |
The pharmacokinetics of DA-8159 and one of its metabolites, DA-8164, were compared after intravenous and oral administration of DA-8159 at a dose of 30 mg/kg to spontaneously hypertensive rats (SHRs) at 16 and 6 weeks old and their respective age-matched control normotensive Kyoto-Wistar rats (KW rats), and deoxycorticosterone acetate-salt-induced hypertensive rats (DOCA-salt rats) at 16 weeks old and their age-matched control Sprague-Dawley rats. After oral administration of DA-8159 to 16-week-old SHRs, the AUC values of both DA-8159 (157 versus 103 microg min/ml) and DA-8164 (215 versus 141 microg min/ml) were significantly greater, but the values of DA-8159 were reversed in 16-week-old DOCA-salt rats (125 versus 200 microg min/ml). However, the AUC values of both DA-8159 and DA-8164 were not significantly different between the 6-week-old SHRs and their control rats. The above AUC differences in 16-week-old SHRs may be due to neither hereditary characteristics of SHRs nor the hypertensive state itself.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0142-2782
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2005 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-20
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16035131-Administration, Oral,
pubmed-meshheading:16035131-Animals,
pubmed-meshheading:16035131-Area Under Curve,
pubmed-meshheading:16035131-Chromatography, High Pressure Liquid,
pubmed-meshheading:16035131-Desoxycorticosterone,
pubmed-meshheading:16035131-Half-Life,
pubmed-meshheading:16035131-Hypertension,
pubmed-meshheading:16035131-Injections, Intravenous,
pubmed-meshheading:16035131-Kidney,
pubmed-meshheading:16035131-Liver,
pubmed-meshheading:16035131-Phosphodiesterase Inhibitors,
pubmed-meshheading:16035131-Piperazines,
pubmed-meshheading:16035131-Purines,
pubmed-meshheading:16035131-Pyrimidines,
pubmed-meshheading:16035131-Rats,
pubmed-meshheading:16035131-Rats, Inbred SHR,
pubmed-meshheading:16035131-Rats, Sprague-Dawley,
pubmed-meshheading:16035131-Sodium Chloride,
pubmed-meshheading:16035131-Sulfonamides,
pubmed-meshheading:16035131-Sulfones
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pubmed:year |
2005
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pubmed:articleTitle |
Pharmacokinetic changes of DA-8159, a new erectogenic, and one of its metabolites, DA-8164 after intravenous and oral administration of DA-8159 to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats.
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pubmed:affiliation |
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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