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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-7-21
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pubmed:abstractText |
Aldosterone is a mineralocorticoid hormone that regulates blood pressure and salt/water balance. Increased aldosterone levels are found in states of disturbed energy balance such as the metabolic syndrome. Adipose tissue has been recognized to play a pivotal role in the regulation of energy homeostasis. We investigated direct aldosterone effects on brown adipocyte function. Aldosterone dose-dependently inhibited expression of uncoupling protein-1 (UCP-1) by 30% (p < 0.01). Furthermore, aldosterone dose-dependently impaired insulin-induced glucose uptake by about 25% (p < 0.01). On a transcriptional level, mRNA of the proinflammatory adipokines leptin and monocyte chemoattractant protein-1 (MCP-1) was increased by 5,000% and 40%, respectively, by aldosterone exposure (p < 0.05). This study demonstrates that aldosterone directly impacts on major adipose functions including stimulation of proinflammatory adipokines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidonecarboxylic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/adipokinetic hormone,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0018-5043
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
455-9
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pubmed:dateRevised |
2009-2-19
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pubmed:meshHeading |
pubmed-meshheading:16034720-Adipocytes,
pubmed-meshheading:16034720-Adipose Tissue, Brown,
pubmed-meshheading:16034720-Aldosterone,
pubmed-meshheading:16034720-Animals,
pubmed-meshheading:16034720-Blotting, Western,
pubmed-meshheading:16034720-Carrier Proteins,
pubmed-meshheading:16034720-Chemokine CCL2,
pubmed-meshheading:16034720-Dose-Response Relationship, Drug,
pubmed-meshheading:16034720-Energy Metabolism,
pubmed-meshheading:16034720-Gene Expression,
pubmed-meshheading:16034720-Glucose,
pubmed-meshheading:16034720-Inflammation,
pubmed-meshheading:16034720-Insect Hormones,
pubmed-meshheading:16034720-Insulin Resistance,
pubmed-meshheading:16034720-Ion Channels,
pubmed-meshheading:16034720-Leptin,
pubmed-meshheading:16034720-Membrane Proteins,
pubmed-meshheading:16034720-Mice,
pubmed-meshheading:16034720-Mitochondrial Proteins,
pubmed-meshheading:16034720-Oligopeptides,
pubmed-meshheading:16034720-Pyrrolidonecarboxylic Acid,
pubmed-meshheading:16034720-RNA, Messenger,
pubmed-meshheading:16034720-Thermogenesis
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pubmed:year |
2005
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pubmed:articleTitle |
Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes.
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pubmed:affiliation |
Department of Internal Medicine I, University of Lübeck, 23538 Lübeck, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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