Linked Life Data

16034177

Source:http://linkedlifedata.com/resource/pubmed/id/16034177

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-7-21
pubmed:abstractText
Unraveling the selective actions of the two pituitary- derived gonadotropins FSH and LH in vivo is complicated by their very close structural and functional similarities, and their coordinate regulation. Both gonadotrophins are composed of a common alpha-subunit and distinct beta-subunits, which are simultaneously secreted as heterodimers in response to a single trophic hormone GnRH. Functionally, gonadotrophins interact with related receptors and share the same ultimate cellular site in the testis, the Sertoli cell with receptors for both FSH and the androgens synthesized in response to LH. This article will review the strategies to overcome these intimate connections and discuss key findings from trans-genic models developed to study gonadotropin actions in the male.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1355-008X
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-39
pubmed:dateRevised
2010-6-24
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Transgenic models for exploring gonadotropin biology in the male.
pubmed:affiliation
ANZAC Research Institute, University of Sydney, Australia.
pubmed:publicationType
Journal Article, Review