| pubmed-article:16034073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C1148932 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C1412076 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C1415585 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:16034073 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:16034073 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16034073 | pubmed:dateCreated | 2005-7-21 | lld:pubmed |
| pubmed-article:16034073 | pubmed:abstractText | HLA-E is an MHC class Ib molecule that binds nonamer peptides derived from the leader sequence of MHC class 1a molecules and is the major ligand for CD94/NKG2 receptors found on NK and T cells. Using the MHC class Ia-null cell line 721.221, we find that surface HLA-E increases following heat shock at 42 degrees C and NK cell-mediated lysis is inhibited using heat-stressed 721.221 targets. We have used mass spectrometry to identify and sequence a novel peptide from HLA-E following heat shock, ALALVRMLI, derived from the transmembrane domain of the human ATP-binding cassette protein, multidrug resistance-associated protein, MRP7. Pulsing 721.221 targets with synthetic MRP7 peptide results in strong inhibition of NK cell-mediated lysis that is reversible using anti-CD94 and anti-class I mAbs. This report is the first to identify a non-MHC leader inhibitory peptide bound to HLA-E and provides insight into the immunoregulatory role of HLA-E during cell stress. | lld:pubmed |
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| pubmed-article:16034073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16034073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16034073 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16034073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16034073 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16034073 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16034073 | pubmed:author | pubmed-author:CotterRobert... | lld:pubmed |
| pubmed-article:16034073 | pubmed:author | pubmed-author:KalbSuzanne... | lld:pubmed |
| pubmed-article:16034073 | pubmed:author | pubmed-author:SoloskiMark... | lld:pubmed |
| pubmed-article:16034073 | pubmed:author | pubmed-author:WoodenStacey... | lld:pubmed |
| pubmed-article:16034073 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16034073 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16034073 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:16034073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16034073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16034073 | pubmed:pagination | 1383-7 | lld:pubmed |
| pubmed-article:16034073 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16034073 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16034073 | pubmed:articleTitle | Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis. | lld:pubmed |
| pubmed-article:16034073 | pubmed:affiliation | Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:16034073 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16034073 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16034073 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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