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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2005-7-21
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pubmed:abstractText |
Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidylcoline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:BombelliCeciliaC,
pubmed-author:CaraccioloGiulioG,
pubmed-author:Di ProfioPietroP,
pubmed-author:DiociaiutiMarcoM,
pubmed-author:LucianiPaolaP,
pubmed-author:ManciniGiovannaG,
pubmed-author:MarraManuelaM,
pubmed-author:MazzucaClaudiaC,
pubmed-author:MolinariAgneseA,
pubmed-author:MontiDonatoD,
pubmed-author:ToccacieliLauraL,
pubmed-author:VenanziMarianoM
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4882-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16033268-Cations,
pubmed-meshheading:16033268-Cell Line, Tumor,
pubmed-meshheading:16033268-Dimyristoylphosphatidylcholine,
pubmed-meshheading:16033268-Fluorescence,
pubmed-meshheading:16033268-Humans,
pubmed-meshheading:16033268-Light,
pubmed-meshheading:16033268-Liposomes,
pubmed-meshheading:16033268-Mesoporphyrins,
pubmed-meshheading:16033268-Microscopy, Confocal,
pubmed-meshheading:16033268-Microscopy, Electron, Transmission,
pubmed-meshheading:16033268-Photochemotherapy,
pubmed-meshheading:16033268-Photosensitizing Agents,
pubmed-meshheading:16033268-Quaternary Ammonium Compounds,
pubmed-meshheading:16033268-Scattering, Radiation,
pubmed-meshheading:16033268-Succinates,
pubmed-meshheading:16033268-Surface-Active Agents,
pubmed-meshheading:16033268-Transition Temperature
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pubmed:year |
2005
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pubmed:articleTitle |
Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physicochemical and biological features of the complexes.
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pubmed:affiliation |
CNR Istituto di Metodologie Chimiche-Sezione Meccanismi di Reazione, and Dipartimento di Chimica, Università degli Studi di Roma "La Sapienza", P.le A. Moro 5, I-00185 Roma, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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