| pubmed-article:16030147 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16030147 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16030147 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16030147 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16030147 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16030147 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:16030147 | lifeskim:mentions | umls-concept:C0033362 | lld:lifeskim |
| pubmed-article:16030147 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:16030147 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:16030147 | pubmed:dateCreated | 2005-7-27 | lld:pubmed |
| pubmed-article:16030147 | pubmed:abstractText | Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has underscored the importance of the insulin B chain region in autoimmunity to pancreatic beta cells. In man, a majority of proteasome cleavage sites are predicted by proteasome cleavage algorithms within this region. To study CD8+ T cell responses to the insulin B chain and adjacent C peptide, we selected 8- to 11-mer peptides according to proteasome cleavage patterns obtained by digestion of two peptides covering proinsulin residues 28 to 64. We studied their binding to purified HLA class I molecules and their recognition by T cells from diabetic patients. Peripheral blood mononuclear cells from 17 of 19 recent-onset and 12 of 13 long-standing type 1 diabetic patients produced IFN-gamma in response to proinsulin peptides as shown by using an ELISPOT assay. In most patients, the response was against several class I-restricted peptides. Nine peptides were recognized within the proinsulin region covering residues 34 to 61. Four yielded a high frequency of recognition in HLA-A1 and -B8 patients. Three peptides located in the proinsulin region 41-51 were shown to bind several HLA molecules and to be recognized in a high percentage of diabetic patients. | lld:pubmed |
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| pubmed-article:16030147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16030147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16030147 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16030147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16030147 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16030147 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:ChoppinJeanni... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:GuilletJean-G... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:CarelJean-Cla... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:BoitardChrist... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:BriandJean-Pa... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:MullerSylvian... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:Caillat-Zucma... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:CamoinLucL | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:ConnanFrancin... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:Dubois-Laforg... | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:TomaAndréaA | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:HaddoukSamyS | lld:pubmed |
| pubmed-article:16030147 | pubmed:author | pubmed-author:GaheryHanneH | lld:pubmed |
| pubmed-article:16030147 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16030147 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:16030147 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:16030147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16030147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16030147 | pubmed:pagination | 10581-6 | lld:pubmed |
| pubmed-article:16030147 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
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| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:meshHeading | pubmed-meshheading:16030147... | lld:pubmed |
| pubmed-article:16030147 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16030147 | pubmed:articleTitle | Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. | lld:pubmed |
