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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-7-20
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pubmed:abstractText |
Cholesterol modified mono-, di-, and tetrameric oligonucleotides were synthesized and hybridized with antisense oligonucleotides to study their incorporation in cationic liposomes together with the influence of this dendrimeric delivery system on biological activity. Electrostatic interactions seem to play the most important role during complexation with cationic lipids. This oligonucleotide formulation gives a small but significant increase in the inhibition of P-glycoprotein expression in a cellular system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
1043-1802
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pubmed:author |
pubmed-author:ChaltinPatrickP,
pubmed-author:De FeyterStevenS,
pubmed-author:De SchryverFransF,
pubmed-author:FisherMichael HMH,
pubmed-author:HerdewijnPietP,
pubmed-author:HerrmannAndreasA,
pubmed-author:JulianoRudolphR,
pubmed-author:KangHyunminH,
pubmed-author:MüllenKlausK,
pubmed-author:MarchandDamienD,
pubmed-author:MargineanuAncaA,
pubmed-author:RozenskiJefJ,
pubmed-author:Van AerschotArthurA
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
827-36
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16029024-3T3 Cells,
pubmed-meshheading:16029024-Animals,
pubmed-meshheading:16029024-Cations,
pubmed-meshheading:16029024-Cholesterol,
pubmed-meshheading:16029024-Fluorescence Resonance Energy Transfer,
pubmed-meshheading:16029024-Lipids,
pubmed-meshheading:16029024-Magnetic Resonance Spectroscopy,
pubmed-meshheading:16029024-Mass Spectrometry,
pubmed-meshheading:16029024-Mice,
pubmed-meshheading:16029024-Oligonucleotides, Antisense
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pubmed:articleTitle |
Delivery of antisense oligonucleotides using cholesterol-modified sense dendrimers and cationic lipids.
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pubmed:affiliation |
Laboratory for Medicinal Chemistry, Rega Institute, Catholic University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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