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pubmed-article:16027806pubmed:abstractTextEquilibrium geometry and electronic structure of three local anesthetic molecules and clonidine were computed. It was shown that clonidine molecule could incorporate into local anesthetic binding centers in potential-operated Na+ channels and in ionic channels coupled to nicotinic cholinergic receptors. The modulatory effect of clonidine on contractile responses of skeletal muscle showed that blockade of Na+ channels and nicotinic cholinergic receptors is a part of its analgesic action.lld:pubmed
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pubmed-article:16027806pubmed:authorpubmed-author:NasledovG AGAlld:pubmed
pubmed-article:16027806pubmed:authorpubmed-author:KatinaI EIElld:pubmed
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pubmed-article:16027806pubmed:articleTitleInhibitory effect of clonidine on cholinergic transmission.lld:pubmed
pubmed-article:16027806pubmed:affiliationV. A. Almazov Cardiology Research Institute, Ministry of Health of the Russian Federation, St. Petersburg. katina@iephb.rulld:pubmed
pubmed-article:16027806pubmed:publicationTypeJournal Articlelld:pubmed
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