|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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|
pubmed:dateCreated |
2005-7-19
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|
pubmed:abstractText |
Equilibrium geometry and electronic structure of three local anesthetic molecules and clonidine were computed. It was shown that clonidine molecule could incorporate into local anesthetic binding centers in potential-operated Na+ channels and in ionic channels coupled to nicotinic cholinergic receptors. The modulatory effect of clonidine on contractile responses of skeletal muscle showed that blockade of Na+ channels and nicotinic cholinergic receptors is a part of its analgesic action.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0007-4888
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
139
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
198-201
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16027806-Adrenergic alpha-Agonists,
pubmed-meshheading:16027806-Analgesics,
pubmed-meshheading:16027806-Anesthetics, Local,
pubmed-meshheading:16027806-Animals,
pubmed-meshheading:16027806-Clonidine,
pubmed-meshheading:16027806-Molecular Structure,
pubmed-meshheading:16027806-Muscle, Skeletal,
pubmed-meshheading:16027806-Muscle Contraction,
pubmed-meshheading:16027806-Nicotinic Antagonists,
pubmed-meshheading:16027806-Synaptic Transmission
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
Inhibitory effect of clonidine on cholinergic transmission.
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|
pubmed:affiliation |
V. A. Almazov Cardiology Research Institute, Ministry of Health of the Russian Federation, St. Petersburg. katina@iephb.ru
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
