Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-7-19
pubmed:abstractText
Viruses have often been observed in association with the dense microvilli of polarized epithelia as well as the filopodia of nonpolarized cells, yet whether interactions with these structures contribute to infection has remained unknown. Here we show that virus binding to filopodia induces a rapid and highly ordered lateral movement, "surfing" toward the cell body before cell entry. Virus cell surfing along filopodia is mediated by the underlying actin cytoskeleton and depends on functional myosin II. Any disruption of virus cell surfing significantly reduces viral infection. Our results reveal another example of viruses hijacking host machineries for efficient infection by using the inherent ability of filopodia to transport ligands to the cell body.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-10482615, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-10559856, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-11106737, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-11221, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-12417576, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-12511869, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-12525631, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-12637748, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-14617360, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-14671127, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-14704683, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-15047824, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-15073366, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-15113894, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-15254191, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-15375270, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-1633624, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-1730005, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-2541919, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-2747796, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-3078414, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-3107838, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-3170637, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-3261635, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-4186808, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-4559927, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-5531377, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-6991511, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-7490299, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-8381123, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-8402880, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-8509456, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-8719872, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-8837776, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-8970739, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-9013340, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-9311787, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-9334344, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-9531561, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-9630212, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-9759843, http://linkedlifedata.com/resource/pubmed/commentcorrection/16027225-9841925
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-25
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells.
pubmed:affiliation
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural