Source:http://linkedlifedata.com/resource/pubmed/id/16026948
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2005-9-28
|
| pubmed:abstractText |
Gamibojungikki-tang (GBIT) has been used for the purpose of development of physical strength in Korea. We investigated the anti-immobility effect of GBIT on the forced swimming test (FST) and then measured the blood biochemical parameters related to fatigue, glucose (Glc); blood urea nitrogen (BUN); lactic dehydrogenase (LDH); creatine kinase (CK) and total protein (TP). GBIT (0.01, 0.1, 1 g/kg) was orally administered to mice for 7 days. After 7 days, the immobility time was significantly decreased in the GBIT-administration group (105.0+/-12.1 s for 1 g/kg) in comparison with the control group (152.3+/-16.2 s). The contents of Glc and TP in the blood serum were significantly increased in GBIT-administration group (1g/kg) compared with control group, while LDH was significantly decreased. Surface phenotyping of spleen cells by FACS analysis revealed an increasing tendency of CD4+ and CD8+ number, without statistical significance. In addition, GBIT (0.01-1 mg/ml) increased the interferon-gamma and interlukin-2 levels in MOLT-4 T-cells. These results suggest that GBIT may be useful in the immune function improvement.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0378-8741
|
| pubmed:author |
pubmed-author:HongSeung-HeonSH,
pubmed-author:KimHyung-MinHM,
pubmed-author:LeeSang HunSH,
pubmed-author:LeeSi-HyeongSH,
pubmed-author:ParkSung-JooSJ,
pubmed-author:ParkYoung-SigYS,
pubmed-author:SeoSang-WanSW,
pubmed-author:ShinHye-YoungHY,
pubmed-author:ShinJo-YoungJY,
pubmed-author:ShinTae-YongTY,
pubmed-author:UmJae-YoungJY,
pubmed-author:YangDeok-ChunDC
|
| pubmed:issnType |
Print
|
| pubmed:day |
31
|
| pubmed:volume |
102
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
113-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:16026948-Animals,
pubmed-meshheading:16026948-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16026948-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16026948-Cell Line,
pubmed-meshheading:16026948-Humans,
pubmed-meshheading:16026948-Interferon-gamma,
pubmed-meshheading:16026948-Interleukin-2,
pubmed-meshheading:16026948-Interleukin-4,
pubmed-meshheading:16026948-Korea,
pubmed-meshheading:16026948-Male,
pubmed-meshheading:16026948-Medicine, Traditional,
pubmed-meshheading:16026948-Mice,
pubmed-meshheading:16026948-Mice, Inbred ICR,
pubmed-meshheading:16026948-Plant Extracts,
pubmed-meshheading:16026948-Plants, Medicinal,
pubmed-meshheading:16026948-Swimming
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Gamibojungikki-tang decreases immobility time on the forced swimming test and increases interferon-gamma production from MOLT-4 cells.
|
| pubmed:affiliation |
College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, South Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|