Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-7-10
pubmed:abstractText
Syncytium induction is a characteristic feature of infection by human immunodeficiency virus (HIV) in vitro. The hydrophobic amino terminus of the transmembrane glycoprotein of HIV type 1 is an essential determinant of virus entry into the target cell population and the formation of syncytia in cell culture. To define the role of the HIV type 2 fusion peptide during infection and syncytium formation, we introduced 8 amino acid substitutions into the hydrophobic amino terminus of gp41, changing either the hydrophobicity, the charge, or the polarity of the amino acid. Viruses containing the envelope mutations were analyzed for their syncytium-inducing capacities, levels of infectivity, and envelope processing and expression. Mutations that increased the hydrophobic nature of the fusion peptide increased syncytium formation, whereas mutations which increased the charge and the polarity and/or decreased the hydrophobicity of the fusion domain severely reduced the capacity of the virus to induce syncytia. However, viruses severely compromised for syncytium formation exhibit only slightly lower levels of infectivity.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-1702159, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-1717715, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-1883204, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2041103, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2117828, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2182910, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2191297, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2236020, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2325207, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2425430, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2541505, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2543131, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2582258, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-2648404, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-3010463, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-3012355, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-3047430, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-3095663, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-3496970, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-3501726, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-3629244, http://linkedlifedata.com/resource/pubmed/commentcorrection/1602558-6189183
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4532-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Role of the fusogenic peptide sequence in syncytium induction and infectivity of human immunodeficiency virus type 2.
pubmed:affiliation
Department of Medicine, University of California, San Diego, La Jolla 92093-0665.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't