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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-7-21
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pubmed:abstractText |
Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we show that the anti-inflammatory action of nicotinic receptor activation in peritoneal macrophages was associated with activation of the transcription factor STAT3. STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha7 subunit of the nicotinic acetylcholine receptor. The anti-inflammatory effect of nicotine required the ability of phosphorylated STAT3 to bind and transactivate its DNA response elements. In a mouse model of intestinal manipulation, stimulation of the vagus nerve ameliorated surgery-induced inflammation and postoperative ileus by activating STAT3 in intestinal macrophages. We conclude that the vagal anti-inflammatory pathway acts by alpha7 subunit-mediated Jak2-STAT3 activation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Jak3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Jak3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/alpha7 nicotinic acetylcholine...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:AkiraShizuoS,
pubmed-author:BenninkRoelof JRJ,
pubmed-author:BerthoudHans-RudolfHR,
pubmed-author:BijlsmaMaarten FMF,
pubmed-author:BoeckxstaensGuy EGE,
pubmed-author:TheFrans OFO,
pubmed-author:UematsuSatoshiS,
pubmed-author:de JongeWouter JWJ,
pubmed-author:van WesterlooDavid JDJ,
pubmed-author:van den WijngaardRene MRM,
pubmed-author:van der ZandenEsmerij PEP
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
844-51
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pubmed:dateRevised |
2010-6-4
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pubmed:meshHeading |
pubmed-meshheading:16025117-Acetylcholine,
pubmed-meshheading:16025117-Animals,
pubmed-meshheading:16025117-Anti-Inflammatory Agents,
pubmed-meshheading:16025117-DNA-Binding Proteins,
pubmed-meshheading:16025117-Dose-Response Relationship, Drug,
pubmed-meshheading:16025117-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16025117-Female,
pubmed-meshheading:16025117-Immunoblotting,
pubmed-meshheading:16025117-Immunohistochemistry,
pubmed-meshheading:16025117-Immunoprecipitation,
pubmed-meshheading:16025117-Inflammation,
pubmed-meshheading:16025117-Interleukin-10,
pubmed-meshheading:16025117-Interleukin-6,
pubmed-meshheading:16025117-Intestines,
pubmed-meshheading:16025117-Janus Kinase 2,
pubmed-meshheading:16025117-Janus Kinase 3,
pubmed-meshheading:16025117-Leukocytes,
pubmed-meshheading:16025117-Macrophage Activation,
pubmed-meshheading:16025117-Macrophages,
pubmed-meshheading:16025117-Male,
pubmed-meshheading:16025117-Mice,
pubmed-meshheading:16025117-Mice, Inbred BALB C,
pubmed-meshheading:16025117-Mice, Inbred C57BL,
pubmed-meshheading:16025117-Nicotine,
pubmed-meshheading:16025117-Phagocytes,
pubmed-meshheading:16025117-Phosphorylation,
pubmed-meshheading:16025117-Protein-Tyrosine Kinases,
pubmed-meshheading:16025117-Proto-Oncogene Proteins,
pubmed-meshheading:16025117-Rats,
pubmed-meshheading:16025117-Rats, Sprague-Dawley,
pubmed-meshheading:16025117-Receptors, Nicotinic,
pubmed-meshheading:16025117-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16025117-STAT3 Transcription Factor,
pubmed-meshheading:16025117-Signal Transduction,
pubmed-meshheading:16025117-Time Factors,
pubmed-meshheading:16025117-Trans-Activators,
pubmed-meshheading:16025117-Transcriptional Activation,
pubmed-meshheading:16025117-Transfection,
pubmed-meshheading:16025117-Vagus Nerve
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pubmed:year |
2005
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pubmed:articleTitle |
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
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pubmed:affiliation |
Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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