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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-1
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pubmed:abstractText |
Phosphatidylserine (PS) exposure is normally associated with apoptosis and the removal of dying cells. We observed that PS is exposed constitutively at high levels on T lymphocytes that express low levels of the transmembrane tyrosine phosphatase CD45RB. CD45 was shown to be a negative regulator of PS translocation in response to various signals, including activation of the ATP receptor P2X(7). Changes in PS distribution were shown to modulate several membrane activities: Ca(2+) and Na(+) uptake through the P2X(7) cation channel itself; P2X(7)-stimulated shedding of the homing receptor CD62L; and reversal of activity of the multidrug transporter P-glycoprotein. The data identify a role for PS distribution changes in signal transduction, rapidly modulating the activities of several membrane proteins. This seems to be an all-or-none effect, coordinating the activity of most or all the molecules of a target protein in each cell. The data also suggest a new approach to circumventing multidrug resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3'-O-(4-benzoyl)benzoyladenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Annexin A5,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/P2rx7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylserines,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X7
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
808-16
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16025105-Adenosine Triphosphate,
pubmed-meshheading:16025105-Animals,
pubmed-meshheading:16025105-Annexin A5,
pubmed-meshheading:16025105-Antigens, CD45,
pubmed-meshheading:16025105-Apoptosis,
pubmed-meshheading:16025105-Biological Transport,
pubmed-meshheading:16025105-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16025105-Calcium,
pubmed-meshheading:16025105-Cell Membrane,
pubmed-meshheading:16025105-Cell Movement,
pubmed-meshheading:16025105-Cell Survival,
pubmed-meshheading:16025105-Drug Resistance, Multiple,
pubmed-meshheading:16025105-Ion Channels,
pubmed-meshheading:16025105-L-Selectin,
pubmed-meshheading:16025105-Lymphocytes,
pubmed-meshheading:16025105-Membrane Proteins,
pubmed-meshheading:16025105-Mice,
pubmed-meshheading:16025105-Mice, Inbred C57BL,
pubmed-meshheading:16025105-Mice, Inbred CBA,
pubmed-meshheading:16025105-Mice, Knockout,
pubmed-meshheading:16025105-Mice, Transgenic,
pubmed-meshheading:16025105-Models, Biological,
pubmed-meshheading:16025105-P-Glycoprotein,
pubmed-meshheading:16025105-Paclitaxel,
pubmed-meshheading:16025105-Phosphatidylserines,
pubmed-meshheading:16025105-Purinergic P2 Receptor Agonists,
pubmed-meshheading:16025105-Receptors, Purinergic P2,
pubmed-meshheading:16025105-Receptors, Purinergic P2X7,
pubmed-meshheading:16025105-Signal Transduction,
pubmed-meshheading:16025105-T-Lymphocyte Subsets
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pubmed:year |
2005
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pubmed:articleTitle |
Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes.
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pubmed:affiliation |
MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. james.elliott@csc.mrc.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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